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000157505 1001_ $$aSaberi Hosnijeh, Fatemeh$$b0
000157505 245__ $$aMediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development.
000157505 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2020
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000157505 520__ $$aSustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case-control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.
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000157505 7001_ $$aKolijn, Pieter M$$b1
000157505 7001_ $$aCasabonne, Delphine$$b2
000157505 7001_ $$aNieters, Alexandra$$b3
000157505 7001_ $$aSolans, Marta$$b4
000157505 7001_ $$aNaudin, Sabine$$b5
000157505 7001_ $$aFerrari, Pietro$$b6
000157505 7001_ $$aMckay, James D$$b7
000157505 7001_ $$aWeiderpass, Elisabete$$b8
000157505 7001_ $$aPerduca, Vittorio$$b9
000157505 7001_ $$aBesson, Caroline$$b10
000157505 7001_ $$aMancini, Francesca Romana$$b11
000157505 7001_ $$aMasala, Giovanna$$b12
000157505 7001_ $$aKrogh, Vittorio$$b13
000157505 7001_ $$aRicceri, Fulvio$$b14
000157505 7001_ $$aHuerta, José M$$b15
000157505 7001_ $$aPetrova, Dafina$$b16
000157505 7001_ $$aSala, Núria$$b17
000157505 7001_ $$aTrichopoulou, Antonia$$b18
000157505 7001_ $$aKarakatsani, Anna$$b19
000157505 7001_ $$aLa Vecchia, Carlo$$b20
000157505 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b21$$udkfz
000157505 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b22$$udkfz
000157505 7001_ $$aAune, Dagfinn$$b23
000157505 7001_ $$aBoeing, Heiner$$b24
000157505 7001_ $$aSchulze, Matthias B$$b25
000157505 7001_ $$aPerez-Cornago, Aurora$$b26
000157505 7001_ $$aLangerak, Anton W$$b27
000157505 7001_ $$avan der Velden, Vincent H J$$b28
000157505 7001_ $$aVermeulen, Roel$$b29
000157505 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-020-70790-9$$gVol. 10, no. 1, p. 13814$$n1$$p13814$$tScientific reports$$v10$$x2045-2322$$y2020
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