TY  - JOUR
AU  - Saberi Hosnijeh, Fatemeh
AU  - Kolijn, Pieter M
AU  - Casabonne, Delphine
AU  - Nieters, Alexandra
AU  - Solans, Marta
AU  - Naudin, Sabine
AU  - Ferrari, Pietro
AU  - Mckay, James D
AU  - Weiderpass, Elisabete
AU  - Perduca, Vittorio
AU  - Besson, Caroline
AU  - Mancini, Francesca Romana
AU  - Masala, Giovanna
AU  - Krogh, Vittorio
AU  - Ricceri, Fulvio
AU  - Huerta, José M
AU  - Petrova, Dafina
AU  - Sala, Núria
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - La Vecchia, Carlo
AU  - Kaaks, Rudolf
AU  - Canzian, Federico
AU  - Aune, Dagfinn
AU  - Boeing, Heiner
AU  - Schulze, Matthias B
AU  - Perez-Cornago, Aurora
AU  - Langerak, Anton W
AU  - van der Velden, Vincent H J
AU  - Vermeulen, Roel
TI  - Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development.
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2020-01665
SP  - 13814
PY  - 2020
AB  - Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case-control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.
LB  - PUB:(DE-HGF)16
C6  - pmid:32796953
DO  - DOI:10.1038/s41598-020-70790-9
UR  - https://inrepo02.dkfz.de/record/157505
ER  -