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@ARTICLE{SaberiHosnijeh:157505,
      author       = {F. Saberi Hosnijeh and P. M. Kolijn and D. Casabonne and A.
                      Nieters and M. Solans and S. Naudin and P. Ferrari and J. D.
                      Mckay and E. Weiderpass and V. Perduca and C. Besson and F.
                      R. Mancini and G. Masala and V. Krogh and F. Ricceri and J.
                      M. Huerta and D. Petrova and N. Sala and A. Trichopoulou and
                      A. Karakatsani and C. La Vecchia and R. Kaaks$^*$ and F.
                      Canzian$^*$ and D. Aune and H. Boeing and M. B. Schulze and
                      A. Perez-Cornago and A. W. Langerak and V. H. J. van der
                      Velden and R. Vermeulen},
      title        = {{M}ediating effect of soluble {B}-cell activation immune
                      markers on the association between anthropometric and
                      lifestyle factors and lymphoma development.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-01665},
      pages        = {13814},
      year         = {2020},
      abstract     = {Sustained B-cell activation is an important mechanism
                      contributing to B-cell lymphoma (BCL). We aimed to validate
                      four previously reported B-cell activation markers
                      predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and
                      to examine their possible mediating effects on the
                      association between anthropometric and lifestyle factors and
                      major BCL subtypes. Pre-diagnostic serum levels were
                      measured for 517 BCL cases and 525 controls in a nested
                      case-control study. The odds ratios of BCL were 6.2 in the
                      highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2
                      for sCD27, and 2.6 for CXCL13. Higher levels of all markers
                      were associated with increased risk of chronic lymphocytic
                      leukemia (CLL), follicular lymphoma (FL), and diffuse large
                      B-cell lymphoma (DLBCL). Following mutual adjustment for the
                      other immune markers, sCD23 remained associated with all
                      subtypes and CXCL13 with FL and DLBCL. The associations of
                      sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted
                      among cases sampled > 9 years before diagnosis. sCD23
                      showed a good predictive ability (area under the
                      curve = 0.80) for CLL, in particular among older, male
                      participants. sCD23 and CXCL13 showed a mediating effect
                      between body mass index (positive) and DLBCL risk, while
                      CXCL13 contributed to the association between physical
                      activity (inverse) and DLBCL. Our data suggest a role of
                      B-cell activation in BCL development and a mediating role of
                      the immune system for lifestyle factors.},
      cin          = {C020 / C055},
      ddc          = {600},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32796953},
      doi          = {10.1038/s41598-020-70790-9},
      url          = {https://inrepo02.dkfz.de/record/157505},
}