TY  - JOUR
AU  - Jakab, Moritz Viktor
AU  - Augustin, Hellmut
TI  - Understanding angiodiversity: insights from single cell biology.
JO  - Development 
VL  - 147
IS  - 15
SN  - 1477-9129
CY  - Cambridge
PB  - The Company of Biologists
M1  - DKFZ-2020-01677
SP  - dev146621 -
PY  - 2020
N1  - #EA:A190#LA:A190#DKFZ-ZMBH Alliance
AB  - Blood vessels have long been considered as passive conduits for delivering blood. However, in recent years, cells of the vessel wall (endothelial cells, smooth muscle cells and pericytes) have emerged as active, highly dynamic components that orchestrate crosstalk between the circulation and organs. Encompassing the whole body and being specialized to the needs of distinct organs, it is not surprising that vessel lining cells come in different flavours. There is calibre-specific specialization (arteries, arterioles, capillaries, venules, veins), but also organ-specific heterogeneity in different microvascular beds (continuous, discontinuous, sinusoidal). Recent technical advances in the field of single cell biology have enabled the profiling of thousands of single cells and, hence, have allowed for the molecular dissection of such angiodiversity, yielding a hitherto unparalleled level of spatial and functional resolution. Here, we review how these approaches have contributed to our understanding of angiodiversity.
LB  - PUB:(DE-HGF)16
C6  - pmid:32792338
DO  - DOI:10.1242/dev.146621
UR  - https://inrepo02.dkfz.de/record/157521
ER  -