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@ARTICLE{Sprute:157614,
      author       = {K. Sprute and V. Kramer and S. Koerber and M. Meneses and
                      R. Fernandez and C. Soza-Ried and M. Eiber and W. Weber and
                      I. Rauscher and K. Rahbar and M. Schaefers and T. Watabe and
                      M. Uemura and S. Naka and N. Nonomura and J. Hatazawa and C.
                      Schwab and V. Schütz and M. Hohenfellner and T.
                      Holland-Letz$^*$ and J. Debus and C. Kratochwil and H.
                      Amaral and P. L. Choyke and U. Haberkorn and C. Sandoval and
                      F. L. Giesel},
      title        = {{D}iagnostic accuracy of 18{F}-{PSMA}-1007-{PET}/{CT}
                      imaging for lymph node staging of prostate carcinoma in
                      primary and biochemical recurrence.},
      journal      = {Journal of nuclear medicine},
      volume       = {62},
      number       = {2},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2020-01711},
      pages        = {208-213},
      year         = {2021},
      note         = {2021 Feb;62(2):208-213},
      abstract     = {Purpose: Prostate specific membrane antigen (PSMA) -ligand
                      PET/CT is performed in patients with prostate cancer to
                      stage the disease initially or to identify sites of
                      recurrence after definitive therapy. 18F-PSMA-1007 is a
                      promising PSMA-PET tracer based on clinical results, but
                      detailed histologic confirmation has been lacking.
                      Experimental Design: 96 patients with prostate cancer
                      received a 18F-PSMA-1007-PET/CT followed by either radical
                      prostatectomy with lymphadenectomy or salvage
                      lymphadenectomy. The histological findings of
                      PSMA-PET-positive nodes were analysed retrospectively. A
                      lesion and a patient-based analysis was performed comparing
                      1) all positive and 2) only lesions with a size larger than
                      3 mm in histopathology. Results: $90.6\%$ of the patients
                      received 18F-PSMA-1007-PET/CT for staging before the primary
                      treatment, while 9.4 $\%$ of the cohort underwent imaging
                      for biochemical recurrence. In $34.4\%$ of the cohort
                      positive lymph nodes were present in imaging. A total of
                      1746 lymph nodes were dissected in 96 patients.
                      18F-PSMA-1007-PET had a lesion-based sensitivity of $81.7\%$
                      a specificity of $99.6\%,$ a positive predictive value (PPV)
                      of $92.4\%,$ a negative predictive value (NPV) of $98.9\%$
                      for detecting positive lymph nodes larger than 3 mm. In the
                      analysis of all malignant nodes regardless the size the
                      overall sensitivity, specificity, PPV, and NPV on
                      lesion-based analysis was $71.2\%,$ $99.5\%,$ $91.3\%,$ and
                      $97.9\%,$ respectively. The patient-based analysis showed a
                      sensitivity of $85.9\%$ and a specificity of $99.5\%$ for
                      lymph nodes >3 mm. Conclusion:18F-PSMA-1007-PET/CT reliably
                      detects malignant lymph nodes and has an exceptional
                      specificity of $>99\%$ for nodal metastases.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32817141},
      doi          = {10.2967/jnumed.120.246363},
      url          = {https://inrepo02.dkfz.de/record/157614},
}