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@ARTICLE{Zheng:157626,
      author       = {G. Zheng$^*$ and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and A. Hemminki and K. Hemminki$^*$},
      title        = {{I}ncidence {D}ifferences {B}etween {F}irst {P}rimary
                      {C}ancers and {S}econd {P}rimary {C}ancers {F}ollowing
                      {S}kin {S}quamous {C}ell {C}arcinoma as {E}tiological
                      {C}lues.},
      journal      = {Clinical epidemiology},
      volume       = {12},
      issn         = {1179-1349},
      address      = {Albany, Auckland},
      publisher    = {Dove Medical Press},
      reportid     = {DKFZ-2020-01723},
      pages        = {857 - 864},
      year         = {2020},
      note         = {#EA:C050#LA:C050#LA:C020#},
      abstract     = {Most literature on second primary cancers (SPCs) focuses on
                      possible factors, which may increase the risk of these
                      cancers, and little attention has been paid for the overall
                      incidence differences between first primary cancers (FPCs)
                      and same SPCs. We wanted to compare the incidence rates for
                      all common cancers when these were diagnosed as FPCs and
                      SPCs after invasive and in situ squamous cell carcinoma
                      (SCC) of the skin, which are usually treated by surgery
                      only.Cancers were identified from the Swedish Cancer
                      Registry from the years 1990 through to 2015, and they
                      included, in addition to skin cancers, 20 male cancers
                      totaling 484,850 patients and 22 female cancers totaling
                      452,909 patients. Standardized incidence rates and relative
                      risks (RRs) were calculated for sex-specific common cancers
                      as FPC and as SPC after skin SCC. Spearman rank correlations
                      were used in the analysis of incidence ranking of FPC and
                      SPC.Of total, 29,061 men and 23,533 women developed invasive
                      SCC and 27,842 men and 36,383 women in situ SCC. The total
                      number of 20 other male cancers was 484,850 and of 22 female
                      cancers it was 452,909. Rank correlations ranged from 0.90
                      to 0.96 (P~5×10-6), indicating that overall skin SCC did
                      not interfere with SPC formation. The exceptions were
                      increased SPC risks for melanoma, sharing risk factors with
                      skin SCC, and non-Hodgkin and Hodgkin lymphoma, and cancers
                      of the upper aerodigestive tract, connective tissue, and
                      male and female genitals suggesting contribution by skin
                      cancer initiated immune dysfunction.The incidence ranking of
                      SPCs after skin cancers largely follows the incidence
                      ranking of FPCs indicating that overall skin SCC does not
                      greatly interfere with the intrinsic carcinogenic process.
                      The main deviations in incidence between FPC and SPC
                      appeared to be due to shared risk factors or immunological
                      processes promoting immune responsive cancer types.},
      cin          = {C050 / HD01 / B062 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32821171},
      pmc          = {pmc:PMC7417931},
      doi          = {10.2147/CLEP.S256662},
      url          = {https://inrepo02.dkfz.de/record/157626},
}