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@ARTICLE{Brenner:157657,
      author       = {H. Brenner$^*$ and B. Holleczek$^*$ and B. Schöttker$^*$},
      title        = {{V}itamin {D} {I}nsufficiency and {D}eficiency and
                      {M}ortality from {R}espiratory {D}iseases in a {C}ohort of
                      {O}lder {A}dults: {P}otential for {L}imiting the {D}eath
                      {T}oll during and beyond the {COVID}-19 {P}andemic?},
      journal      = {Nutrients},
      volume       = {12},
      number       = {8},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-01745},
      pages        = {2488},
      year         = {2020},
      note         = {#EA:C070#LA:C070#},
      abstract     = {The COVID-19 pandemic goes along with increased mortality
                      from acute respiratory disease. It has been suggested that
                      vitamin D3 supplementation might help to reduce respiratory
                      disease mortality. We assessed the prevalence of vitamin D
                      insufficiency and deficiency, defined by 25-hydroxyvitamin D
                      (25(OH)D) blood levels of 30-50 and <30 nmol/L,
                      respectively, and their association with mortality from
                      respiratory diseases during 15 years of follow-up in a
                      cohort of 9548 adults aged 50-75 years from Saarland,
                      Germany. Vitamin D insufficiency and deficiency were common
                      $(44\%$ and $15\%,$ respectively). Compared to those with
                      sufficient vitamin D status, participants with vitamin D
                      insufficiency and deficiency had strongly increased
                      respiratory mortality, with adjusted hazard ratios $(95\%$
                      confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2)
                      overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and
                      1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, $41\%$
                      $(95\%$ confidence interval: $20-58\%)$ of respiratory
                      disease mortality was statistically attributable to vitamin
                      D insufficiency or deficiency. Vitamin D insufficiency and
                      deficiency are common and account for a large proportion of
                      respiratory disease mortality in older adults, supporting
                      the hypothesis that vitamin D3 supplementation could be
                      helpful to limit the burden of the COVID-19 pandemic,
                      particularly among women.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32824839},
      doi          = {10.3390/nu12082488},
      url          = {https://inrepo02.dkfz.de/record/157657},
}