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@ARTICLE{Repky:163006,
      author       = {S. Repky and G. Büchele and K.-P. Günther and K. Huch and
                      H. Brenner$^*$ and T. Stürmer and J. Beyersmann and R. E.
                      Brenner and D. Rothenbacher},
      title        = {{F}ive years' trajectories of functionality and pain in
                      patients after hip or knee replacement and association with
                      long-term patient survival.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-01799},
      pages        = {14388},
      year         = {2020},
      abstract     = {To describe the 5 years' trajectories in functionality and
                      pain of patients with hip or knee osteoarthritis and
                      arthroplasty and analyze the association of these with
                      long-term patients survival. Patients with OA receiving
                      total hip or knee arthroplasty were recruited and completed
                      two sets of standardized questionnaires for functionality
                      and pain 6, 12, and 60 months postoperatively. Multivariate
                      mixed models were conducted to assess trajectories over time
                      and the resulting improvement per month during the last time
                      period was included in a landmark-model to estimate adjusted
                      hazard ratios for mortality. In total 809 patients with
                      joint replacement were included (mean age 65.0 years,
                      $62.2\%$ female), 407 patients died (median follow-up
                      18.4 years). Both instruments of functionality and pain
                      showed extensive improvement during the first 6 months.
                      Baseline and change in functionality (both p < 0.001)
                      and pain (p = 0.02) during the first 6 months were
                      associated with mortality. Better values in functionality
                      corresponded with improved survival whereas the association
                      with the pain scores was inverse. In patients with hip and
                      knee OA, an explicit improvement in function is seen within
                      the first 6 months after arthroplasty. In addition,
                      especially the functionality scores at baseline as well as
                      their improvement showed an association with long-term
                      patient survival.},
      cin          = {C070},
      ddc          = {600},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32873877},
      pmc          = {pmc:PMC7463234},
      doi          = {10.1038/s41598-020-71277-3},
      url          = {https://inrepo02.dkfz.de/record/163006},
}