%0 Journal Article
%A Darr, Christopher
%A Finis, Friederike
%A Wiesenfarth, Manuel
%A Giganti, Francesco
%A Tschirdewahn, Stephan
%A Krafft, Ulrich
%A Kesch, Claudia
%A Bonekamp, David
%A Forsting, Michael
%A Wetter, Axel
%A Reis, Henning
%A Hadaschik, Boris A
%A Haubold, Johannes
%A Radtke, Jan Philipp
%T Three-dimensional Magnetic Resonance Imaging-based Printed Models of Prostate Anatomy and Targeted Biopsy-proven Index Tumor to Facilitate Patient-tailored Radical Prostatectomy-A Feasibility Study.
%J European urology oncology
%V 5
%N 3
%@ 2588-9311
%C Amsterdam
%I Elsevier
%M DKFZ-2020-01803
%P 357-361
%D 2022
%Z Volume 5, Issue 3, June 2022, Pages 357-361
%X In this prospective single-center feasibility study, we demonstrate that the use of three-dimensional (3D)-printed prostate models support nerve-sparing radical prostatectomy (RP) and intraoperative frozen sectioning (IFS) in ten men suffering from intermediate- and high-risk prostate cancer (PC), of whom seven harbored pT3 disease. Patient-specific 3D resin models were printed based on preoperative multiparametric magnetic resonance imaging (mpMRI) to provide an exact 3D impression of significant tumor lesions. RP and IFS were planned in a patient-tailored fashion. The 36-region Prostate Imaging Reporting and Data System (PI-RADS) v2.0 scheme was used to compare the MRI/3D print with whole-mount histopathology. In all cases, localization of the index lesion was correctly displayed by MRI and the 3D model. Localization of significant PC lesions correlated significantly (Pearson`s correlation coefficient of 0.88; p <  0.001). In addition, a significant correlation of the width, length, and volume of the tumor and prostate gland, derived from the printed model and histopathology, was found, using Pearson's correlation analyses and Bland-Altman plots. In conclusion, 3D-printed prostate models correlate well with final pathology and can be used to tailor RP. PATIENT SUMMARY: The use of three-dimensional (3D)-printed prostate models based on preoperative magnetic resonance imaging (MRI) may improve prostatectomy outcome. This study confirmed the accuracy of 3D-printed prostates compared with pathology from radical prostatectomy specimens. Thus, MRI-derived 3D-printed prostate models can assist in prostate cancer surgery.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32873530
%R 10.1016/j.euo.2020.08.004
%U https://inrepo02.dkfz.de/record/163010