TY  - JOUR
AU  - Darr, Christopher
AU  - Finis, Friederike
AU  - Wiesenfarth, Manuel
AU  - Giganti, Francesco
AU  - Tschirdewahn, Stephan
AU  - Krafft, Ulrich
AU  - Kesch, Claudia
AU  - Bonekamp, David
AU  - Forsting, Michael
AU  - Wetter, Axel
AU  - Reis, Henning
AU  - Hadaschik, Boris A
AU  - Haubold, Johannes
AU  - Radtke, Jan Philipp
TI  - Three-dimensional Magnetic Resonance Imaging-based Printed Models of Prostate Anatomy and Targeted Biopsy-proven Index Tumor to Facilitate Patient-tailored Radical Prostatectomy-A Feasibility Study.
JO  - European urology oncology
VL  - 5
IS  - 3
SN  - 2588-9311
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2020-01803
SP  - 357-361
PY  - 2022
N1  - Volume 5, Issue 3, June 2022, Pages 357-361
AB  - In this prospective single-center feasibility study, we demonstrate that the use of three-dimensional (3D)-printed prostate models support nerve-sparing radical prostatectomy (RP) and intraoperative frozen sectioning (IFS) in ten men suffering from intermediate- and high-risk prostate cancer (PC), of whom seven harbored pT3 disease. Patient-specific 3D resin models were printed based on preoperative multiparametric magnetic resonance imaging (mpMRI) to provide an exact 3D impression of significant tumor lesions. RP and IFS were planned in a patient-tailored fashion. The 36-region Prostate Imaging Reporting and Data System (PI-RADS) v2.0 scheme was used to compare the MRI/3D print with whole-mount histopathology. In all cases, localization of the index lesion was correctly displayed by MRI and the 3D model. Localization of significant PC lesions correlated significantly (Pearson`s correlation coefficient of 0.88; p <  0.001). In addition, a significant correlation of the width, length, and volume of the tumor and prostate gland, derived from the printed model and histopathology, was found, using Pearson's correlation analyses and Bland-Altman plots. In conclusion, 3D-printed prostate models correlate well with final pathology and can be used to tailor RP. PATIENT SUMMARY: The use of three-dimensional (3D)-printed prostate models based on preoperative magnetic resonance imaging (MRI) may improve prostatectomy outcome. This study confirmed the accuracy of 3D-printed prostates compared with pathology from radical prostatectomy specimens. Thus, MRI-derived 3D-printed prostate models can assist in prostate cancer surgery.
LB  - PUB:(DE-HGF)16
C6  - pmid:32873530
DO  - DOI:10.1016/j.euo.2020.08.004
UR  - https://inrepo02.dkfz.de/record/163010
ER  -