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@ARTICLE{Darr:163010,
      author       = {C. Darr$^*$ and F. Finis$^*$ and M. Wiesenfarth$^*$ and F.
                      Giganti and S. Tschirdewahn$^*$ and U. Krafft$^*$ and C.
                      Kesch$^*$ and D. Bonekamp$^*$ and M. Forsting$^*$ and A.
                      Wetter$^*$ and H. Reis$^*$ and B. A. Hadaschik$^*$ and J.
                      Haubold$^*$ and J. P. Radtke$^*$},
      title        = {{T}hree-dimensional {M}agnetic {R}esonance {I}maging-based
                      {P}rinted {M}odels of {P}rostate {A}natomy and {T}argeted
                      {B}iopsy-proven {I}ndex {T}umor to {F}acilitate
                      {P}atient-tailored {R}adical {P}rostatectomy-{A}
                      {F}easibility {S}tudy.},
      journal      = {European urology oncology},
      volume       = {5},
      number       = {3},
      issn         = {2588-9311},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01803},
      pages        = {357-361},
      year         = {2022},
      note         = {Volume 5, Issue 3, June 2022, Pages 357-361},
      abstract     = {In this prospective single-center feasibility study, we
                      demonstrate that the use of three-dimensional (3D)-printed
                      prostate models support nerve-sparing radical prostatectomy
                      (RP) and intraoperative frozen sectioning (IFS) in ten men
                      suffering from intermediate- and high-risk prostate cancer
                      (PC), of whom seven harbored pT3 disease. Patient-specific
                      3D resin models were printed based on preoperative
                      multiparametric magnetic resonance imaging (mpMRI) to
                      provide an exact 3D impression of significant tumor lesions.
                      RP and IFS were planned in a patient-tailored fashion. The
                      36-region Prostate Imaging Reporting and Data System
                      (PI-RADS) v2.0 scheme was used to compare the MRI/3D print
                      with whole-mount histopathology. In all cases, localization
                      of the index lesion was correctly displayed by MRI and the
                      3D model. Localization of significant PC lesions correlated
                      significantly (Pearson`s correlation coefficient of 0.88;
                      p <  0.001). In addition, a significant correlation of
                      the width, length, and volume of the tumor and prostate
                      gland, derived from the printed model and histopathology,
                      was found, using Pearson's correlation analyses and
                      Bland-Altman plots. In conclusion, 3D-printed prostate
                      models correlate well with final pathology and can be used
                      to tailor RP. PATIENT SUMMARY: The use of three-dimensional
                      (3D)-printed prostate models based on preoperative magnetic
                      resonance imaging (MRI) may improve prostatectomy outcome.
                      This study confirmed the accuracy of 3D-printed prostates
                      compared with pathology from radical prostatectomy
                      specimens. Thus, MRI-derived 3D-printed prostate models can
                      assist in prostate cancer surgery.},
      cin          = {ED01 / C060 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32873530},
      doi          = {10.1016/j.euo.2020.08.004},
      url          = {https://inrepo02.dkfz.de/record/163010},
}