TY  - JOUR
AU  - Seyed Khoei, Nazlisadat
AU  - Jenab, Mazda
AU  - Murphy, Neil
AU  - Banbury, Barbara L
AU  - Carreras-Torres, Robert
AU  - Viallon, Vivian
AU  - Kühn, Tilman
AU  - Bueno-de-Mesquita, Bas
AU  - Aleksandrova, Krasimira
AU  - Cross, Amanda J
AU  - Weiderpass, Elisabete
AU  - Stepien, Magdalena
AU  - Bulmer, Andrew
AU  - Tjønneland, Anne
AU  - Boutron-Ruault, Marie-Christine
AU  - Severi, Gianluca
AU  - Carbonnel, Franck
AU  - Katzke, Verena
AU  - Boeing, Heiner
AU  - Bergmann, Manuela M
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - Martimianaki, Georgia
AU  - Palli, Domenico
AU  - Tagliabue, Giovanna
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Skeie, Guri
AU  - Merino, Susana
AU  - Bonet, Catalina
AU  - Rodríguez-Barranco, Miguel
AU  - Gil, Leire
AU  - Chirlaque, Maria-Dolores
AU  - Ardanaz, Eva
AU  - Myte, Robin
AU  - Hultdin, Johan
AU  - Perez-Cornago, Aurora
AU  - Aune, Dagfinn
AU  - Tsilidis, Konstantinos K
AU  - Albanes, Demetrius
AU  - Baron, John A
AU  - Berndt, Sonja I
AU  - Bézieau, Stéphane
AU  - Brenner, Hermann
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Chanock, Stephen J
AU  - Cotterchio, Michelle
AU  - Gallinger, Steven
AU  - Gruber, Stephen B
AU  - Haile, Robert W
AU  - Hampe, Jochen
AU  - Hoffmeister, Michael
AU  - Hopper, John L
AU  - Hsu, Li
AU  - Huyghe, Jeroen R
AU  - Jenkins, Mark A
AU  - Joshi, Amit D
AU  - Kampman, Ellen
AU  - Larsson, Susanna C
AU  - Le Marchand, Loic
AU  - Li, Christopher I
AU  - Li, Li
AU  - Lindblom, Annika
AU  - Lindor, Noralane M
AU  - Martín, Vicente
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Offit, Kenneth
AU  - Ogino, Shuji
AU  - Parfrey, Patrick S
AU  - Pharoah, Paul D P
AU  - Rennert, Gad
AU  - Sakoda, Lori C
AU  - Schafmayer, Clemens
AU  - Schmit, Stephanie L
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - Thibodeau, Stephen N
AU  - Ulrich, Cornelia M
AU  - van Duijnhoven, Franzel J B
AU  - Weigl, Korbinian
AU  - Weinstein, Stephanie J
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Zhang, Xuehong
AU  - Ferrari, Pietro
AU  - Anton, Gabriele
AU  - Peters, Annette
AU  - Peters, Ulrike
AU  - Gunter, Marc J
AU  - Wagner, Karl-Heinz
AU  - Freisling, Heinz
TI  - Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
JO  - BMC medicine
VL  - 18
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2020-01811
SP  - 229
PY  - 2020
AB  - Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex.In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.The associations between circulating UCB levels and CRC risk differed by sex (Pheterogeneity = 0.008). Among men, higher levels of UCB were positively associated with CRC risk (odds ratio [OR] = 1.19, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32878631
C2  - pmc:PMC7469292
DO  - DOI:10.1186/s12916-020-01703-w
UR  - https://inrepo02.dkfz.de/record/163020
ER  -