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@ARTICLE{Christakoudi:163026,
      author       = {S. Christakoudi and K. K. Tsilidis and D. C. Muller and H.
                      Freisling and E. Weiderpass and K. Overvad and S. Söderberg
                      and C. Häggström and T. Pischon and C. C. Dahm and J.
                      Zhang and A. Tjønneland and J. Halkjær and C. MacDonald
                      and M.-C. Boutron-Ruault and F. R. Mancini and T. Kühn$^*$
                      and R. Kaaks$^*$ and M. B. Schulze and A. Trichopoulou and
                      A. Karakatsani and E. Peppa and G. Masala and V. Pala and S.
                      Panico and R. Tumino and C. Sacerdote and J. R. Quirós and
                      A. Agudo and M.-J. Sánchez and L. Cirera and A.
                      Barricarte-Gurrea and P. Amiano and E. Memarian and E.
                      Sonestedt and B. Bueno-de-Mesquita and A. M. May and K.-T.
                      Khaw and N. J. Wareham and T. Y. N. Tong and I. Huybrechts
                      and H. Noh and E. K. Aglago and M. Ellingjord-Dale and H. A.
                      Ward and D. Aune and E. Riboli},
      title        = {{A} {B}ody {S}hape {I}ndex ({ABSI}) achieves better
                      mortality risk stratification than alternative indices of
                      abdominal obesity: results from a large {E}uropean cohort.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-01817},
      pages        = {14541},
      year         = {2020},
      abstract     = {Abdominal and general adiposity are independently
                      associated with mortality, but there is no consensus on how
                      best to assess abdominal adiposity. We compared the ability
                      of alternative waist indices to complement body mass index
                      (BMI) when assessing all-cause mortality. We used data from
                      352,985 participants in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) and Cox
                      proportional hazards models adjusted for other risk factors.
                      During a mean follow-up of 16.1 years, 38,178 participants
                      died. Combining in one model BMI and a strongly correlated
                      waist index altered the association patterns with mortality,
                      to a predominantly negative association for BMI and a
                      stronger positive association for the waist index, while
                      combining BMI with the uncorrelated A Body Shape Index
                      (ABSI) preserved the association patterns. Sex-specific
                      cohort-wide quartiles of waist indices correlated with BMI
                      could not separate high-risk from low-risk individuals
                      within underweight (BMI < 18.5 kg/m2) or obese
                      (BMI ≥ 30 kg/m2) categories, while the highest
                      quartile of ABSI separated $18-39\%$ of the individuals
                      within each BMI category, which had $22-55\%$ higher risk of
                      death. In conclusion, only a waist index independent of BMI
                      by design, such as ABSI, complements BMI and enables
                      efficient risk stratification, which could facilitate
                      personalisation of screening, treatment and monitoring.},
      cin          = {C020},
      ddc          = {600},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32883969},
      pmc          = {pmc:PMC7471961},
      doi          = {10.1038/s41598-020-71302-5},
      url          = {https://inrepo02.dkfz.de/record/163026},
}