% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schmidt:163032,
      author       = {M. Schmidt$^*$ and S. Hermann$^*$ and V. Arndt$^*$ and K.
                      Steindorf$^*$},
      title        = {{P}revalence and severity of long-term physical, emotional,
                      and cognitive fatigue across 15 different cancer entities.},
      journal      = {Cancer medicine},
      volume       = {9},
      number       = {21},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2020-01823},
      pages        = {8053-8061},
      year         = {2020},
      note         = {#EA:C110#LA:C110# 2020 Nov;9(21):8053-8061},
      abstract     = {Fatigue prevalence and severity have been assessed in a
                      variety of studies, yet, not in a standardized way, and
                      predominantly in breast cancer patients. Systematic,
                      comparative investigations across a broad range of cancer
                      entities are lacking.The FiX study systematically enrolled
                      2244 cancer patients across 15 entities approximately
                      2 years after diagnosis. Fatigue was assessed with the
                      multidimensional EORTC QLQ-FA12 questionnaire. Physical,
                      emotional, cognitive, and total fatigue were compared across
                      entities and with normative values of the general
                      population. Differences in patients' characteristics and
                      cancer therapy between entities were taken into account
                      using analyses of covariance models.Across all entities,
                      mean physical fatigue levels were significantly higher than
                      age- and sex-matched means of the general population for all
                      cancer entities (all Bonferroni-Holm adjusted P < .01).
                      For most entities also emotional and cognitive fatigue
                      levels were significantly higher than normative values. Age-
                      and sex-standardized physical fatigue prevalence ranged from
                      $31.8\%$ among prostate to $51.7\%$ among liver cancer
                      patients. Differences between entities could not be fully
                      explained by sex, age, BMI, or cancer therapy. Adjusted for
                      these factors, mean physical fatigue was higher for stomach
                      (P = .0004), lung (P = .034), kidney (P = .0011),
                      pancreas (P = .081), and endometrium (P = .022) compared
                      to breast cancer patients. Adjusted means of emotional
                      fatigue were also lowest in breast cancer patients and
                      significantly higher in stomach (P = .0047), bladder
                      (P = .0036), and rectal (P = .0020) cancer
                      patients.Physical, emotional, and cognitive fatigue is
                      prevalent in all 15 investigated cancer entities even
                      2 years after diagnosis. Fatigue in breast cancer patients,
                      the so-far most studied group, is in the lowest range among
                      all entities, suggesting that the extent of fatigue is still
                      insufficiently determined. Entity-specific problems might
                      need to be considered in the treatment of fatigue.},
      cin          = {C110 / M110 / C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331 / I:(DE-He78)M110-20160331 /
                      I:(DE-He78)C071-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32893501},
      doi          = {10.1002/cam4.3413},
      url          = {https://inrepo02.dkfz.de/record/163032},
}