TY  - JOUR
AU  - Bundred, James
AU  - Michael, Sarah
AU  - Bowers, Sarah
AU  - Barnes, Nicola
AU  - Jauhari, Yasmin
AU  - Plant, Dafydd
AU  - Maishman, Thomas
AU  - Cutress, Ramsey
AU  - Holleczek, Bernd
AU  - Dodwell, David
AU  - Bundred, Nigel
TI  - Do surgical margins matter after mastectomy? A systematic review.
JO  - European journal of surgical oncology
VL  - 46
IS  - 12
SN  - 0748-7983
CY  - Burlington, Mass.
PB  - Harcourt
M1  - DKFZ-2020-01838
SP  - 2185-2194
PY  - 2020
N1  - 2020 Dec;46(12):2185-2194
AB  - No consensus exists regarding adequacy of margins after mastectomy. To determine if pathological margin proximity is associated with local (LR) or distant recurrence after mastectomy for early invasive breast cancer or ductal carcinoma in situ.A systematic review of literature published from 1980 to 2019 and meta-analysis was conducted. Unpublished data were sought from authors (PROSPERO (CRD42019127541)). Thirty-four studies comprising 34,833 breast cancer patients were included in the quantitative synthesis. Eligible studies reported on patients undergoing curative mastectomy for cancer allowing estimation of outcomes in relation to margin status/width. The association between pathological margin status and local (LR) and distant recurrence was considered using random effects modelling. PRISMA guidelines were followed.Positive margins were associated with increased LR on multivariable analyses (HR, 2·64, (95
LB  - PUB:(DE-HGF)16
C6  - pmid:32907774
DO  - DOI:10.1016/j.ejso.2020.08.015
UR  - https://inrepo02.dkfz.de/record/163052
ER  -