%0 Journal Article
%A Wennmann, Markus
%A Hielscher, Thomas
%A Kintzelé, Laurent
%A Menze, Bjoern H
%A Langs, Georg
%A Merz, Maximilian
%A Sauer, Sandra
%A Kauczor, Hans-Ulrich
%A Schlemmer, Heinz-Peter
%A Delorme, Stefan
%A Goldschmidt, Hartmut
%A Weinhold, Niels
%A Hillengass, Jens
%A Weber, Marc-André
%T Spatial Distribution of Focal Lesions in Whole-Body MRI and Influence of MRI Protocol on Staging in Patients with Smoldering Multiple Myeloma According to the New SLiM-CRAB-Criteria.
%J Cancers
%V 12
%N 9
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2020-01839
%P 2537
%D 2020
%Z #EA:E010#
%X The purpose of this study was to assess how different MRI protocols (spinal vs. spinal plus pelvic vs. whole-body (wb)-MRI) affect staging in patients with smoldering multiple myeloma (SMM), according to the SLiM-CRAB-criterion '>1 focal lesion (FL) in MRI'. In this retrospective study, a baseline cohort of 147 SMM patients with wb-MRI at initial diagnosis was investigated, including prognostic data regarding development of CRAB-criteria. Fifty-two patients formed a follow-up cohort with a median of three wb-MRIs. The locations of all FLs were determined and it was calculated how staging decisions regarding the criterion '>1 FL in MRI' would have been made if only a limited anatomic area (spine vs. spine plus pelvis) would have been covered by the MRI protocol. Furthermore, subgroups of patients selected by different cutoff-protocol-combinations were compared regarding their prognosis for development of CRAB-criteria. With an MRI protocol limited to spine/spine plus pelvis, only 28
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32906608
%R 10.3390/cancers12092537
%U https://inrepo02.dkfz.de/record/163053