TY  - JOUR
AU  - Wennmann, Markus
AU  - Hielscher, Thomas
AU  - Kintzelé, Laurent
AU  - Menze, Bjoern H
AU  - Langs, Georg
AU  - Merz, Maximilian
AU  - Sauer, Sandra
AU  - Kauczor, Hans-Ulrich
AU  - Schlemmer, Heinz-Peter
AU  - Delorme, Stefan
AU  - Goldschmidt, Hartmut
AU  - Weinhold, Niels
AU  - Hillengass, Jens
AU  - Weber, Marc-André
TI  - Spatial Distribution of Focal Lesions in Whole-Body MRI and Influence of MRI Protocol on Staging in Patients with Smoldering Multiple Myeloma According to the New SLiM-CRAB-Criteria.
JO  - Cancers
VL  - 12
IS  - 9
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-01839
SP  - 2537
PY  - 2020
N1  - #EA:E010#
AB  - The purpose of this study was to assess how different MRI protocols (spinal vs. spinal plus pelvic vs. whole-body (wb)-MRI) affect staging in patients with smoldering multiple myeloma (SMM), according to the SLiM-CRAB-criterion '>1 focal lesion (FL) in MRI'. In this retrospective study, a baseline cohort of 147 SMM patients with wb-MRI at initial diagnosis was investigated, including prognostic data regarding development of CRAB-criteria. Fifty-two patients formed a follow-up cohort with a median of three wb-MRIs. The locations of all FLs were determined and it was calculated how staging decisions regarding the criterion '>1 FL in MRI' would have been made if only a limited anatomic area (spine vs. spine plus pelvis) would have been covered by the MRI protocol. Furthermore, subgroups of patients selected by different cutoff-protocol-combinations were compared regarding their prognosis for development of CRAB-criteria. With an MRI protocol limited to spine/spine plus pelvis, only 28
LB  - PUB:(DE-HGF)16
C6  - pmid:32906608
DO  - DOI:10.3390/cancers12092537
UR  - https://inrepo02.dkfz.de/record/163053
ER  -