TY  - JOUR
AU  - Amadou, Amina
AU  - Coudon, Thomas
AU  - Praud, Delphine
AU  - Salizzoni, Pietro
AU  - Leffondre, Karen
AU  - Lévêque, Emilie
AU  - Boutron-Ruault, Marie-Christine
AU  - Danjou, Aurélie M N
AU  - Morelli, Xavier
AU  - Le Cornet, Charlotte
AU  - Perrier, Lionel
AU  - Couvidat, Florian
AU  - Bessagnet, Bertrand
AU  - Caudeville, Julien
AU  - Faure, Elodie
AU  - Mancini, Francesca Romana
AU  - Gulliver, John
AU  - Severi, Gianluca
AU  - Fervers, Béatrice
TI  - Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort.
JO  - JMIR Research Protocols
VL  - 9
IS  - 9
SN  - 1929-0748
CY  - Toronto
M1  - DKFZ-2020-01900
SP  - e15167 
PY  - 2020
AB  - Breast cancer is the most frequent cancer in women in industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role in breast cancer risk. Current epidemiological studies, although not fully consistent, suggest a positive association of breast cancer risk with exposure to several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB), dioxins, Benzo[a]pyrene (BaP), and cadmium. However, epidemiological studies remain scarce and inconsistent. It has been proposed that the menopausal status could modify the relationship between pollutants and breast cancer and that the association varies with hormone receptor status.The XENAIR project will investigate the association of breast cancer risk (overall and by hormone receptor status) with chronic exposure to selected air pollutants, including particulate matter, nitrogen dioxide (NO2), ozone (O3), BaP, dioxins, PCB-153, and cadmium.Our research is based on a case-control study nested within the French national E3N cohort of 5222 invasive breast cancer cases identified during follow-up from 1990 to 2011, and 5222 matched controls. A questionnaire was sent to all participants to collect their lifetime residential addresses and information on indoor pollution. We will assess these exposures using complementary models of land-use regression, atmospheric dispersion, and regional chemistry-transport (CHIMERE) models, via a Geographic Information System. Associations with breast cancer risk will be modeled using conditional logistic regression models. We will also study the impact of exposure on DNA methylation and interactions with genetic polymorphisms. Appropriate statistical methods, including Bayesian modeling, principal component analysis, and cluster analysis, will be used to assess the impact of multipollutant exposure. The fraction of breast cancer cases attributable to air pollution will be estimated.The XENAIR project will contribute to current knowledge on the health effects of air pollution and identify and understand environmental modifiable risk factors related to breast cancer risk.The results will provide relevant evidence to governments and policy-makers to improve effective public health prevention strategies on air pollution. The XENAIR dataset can be used in future efforts to study the effects of exposure to air pollution associated with other chronic conditions.DERR1-10.2196/15167.
LB  - PUB:(DE-HGF)16
C6  - pmid:32930673
DO  - DOI:10.2196/15167
UR  - https://inrepo02.dkfz.de/record/163203
ER  -