%0 Journal Article
%A Gonzalez Maldonado, Sandra
%A Motsch, Erna
%A Trotter, Anke
%A Kauczor, Hans-Ulrich
%A Heussel, Claus-Peter
%A Hermann, Silke
%A Zeissig, Sylke Ruth
%A Delorme, Stefan
%A Kaaks, Rudolf
%T Overdiagnosis in lung cancer screening - estimates from the German Lung Cancer Screening Intervention Trial.
%J International journal of cancer
%V 148
%N 5
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2020-01904
%P 1097-1105
%D 2021
%Z #EA:C020#LA:C020#2021 Mar 1;148(5):1097-1105 /  https://doi.org/10.1002/ijc.33295
%X Overdiagnosis is a major potential harm of lung cancer screening; knowing its potential magnitude helps to optimize screening eligibility criteria. The German Lung Screening Intervention Trial ('LUSI') is a randomized trial among 4052 long-term smokers (2622 men), 50.3-71.9 years of age from the general population around Heidelberg, Germany, comparing five annual rounds of low-dose computed tomography (n=2029) with a control arm without intervention (n=2023). After a median follow-up of 9.77 years post-randomization and 5.73 years since last screening, 74 participants were diagnosed with lung cancer in the control arm and 90 in the screening arm: 69 during the active screening period; of which 63 screen-detected and 6 interval cancers. The excess cumulative incidence in the screening arm (N=16) represented 25.4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32930386
%R 10.1002/ijc.33295
%U https://inrepo02.dkfz.de/record/163207