TY  - JOUR
AU  - Gonzalez Maldonado, Sandra
AU  - Motsch, Erna
AU  - Trotter, Anke
AU  - Kauczor, Hans-Ulrich
AU  - Heussel, Claus-Peter
AU  - Hermann, Silke
AU  - Zeissig, Sylke Ruth
AU  - Delorme, Stefan
AU  - Kaaks, Rudolf
TI  - Overdiagnosis in lung cancer screening - estimates from the German Lung Cancer Screening Intervention Trial.
JO  - International journal of cancer
VL  - 148
IS  - 5
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2020-01904
SP  - 1097-1105
PY  - 2021
N1  - #EA:C020#LA:C020#2021 Mar 1;148(5):1097-1105 /  https://doi.org/10.1002/ijc.33295
AB  - Overdiagnosis is a major potential harm of lung cancer screening; knowing its potential magnitude helps to optimize screening eligibility criteria. The German Lung Screening Intervention Trial ('LUSI') is a randomized trial among 4052 long-term smokers (2622 men), 50.3-71.9 years of age from the general population around Heidelberg, Germany, comparing five annual rounds of low-dose computed tomography (n=2029) with a control arm without intervention (n=2023). After a median follow-up of 9.77 years post-randomization and 5.73 years since last screening, 74 participants were diagnosed with lung cancer in the control arm and 90 in the screening arm: 69 during the active screening period; of which 63 screen-detected and 6 interval cancers. The excess cumulative incidence in the screening arm (N=16) represented 25.4
LB  - PUB:(DE-HGF)16
C6  - pmid:32930386
DO  - DOI:10.1002/ijc.33295
UR  - https://inrepo02.dkfz.de/record/163207
ER  -