TY  - JOUR
AU  - Alwers, Elizabeth
AU  - Jansen, Lina
AU  - Kather, Jakob
AU  - Amitay, Efrat
AU  - Bläker, Hendrik
AU  - Kloor, Matthias
AU  - Tagscherer, Katrin E
AU  - Roth, Wilfried
AU  - Herpel, Esther
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort.
JO  - International journal of colorectal disease
VL  - 36
IS  - 1
SN  - 1432-1262
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2020-01914
SP  - 177-185
PY  - 2021
N1  - #EA:C070#LA:C070#2021 Jan;36(1):177-185
AB  - In rectal cancer, prediction of tumor response and pathological complete response (pCR) to neoadjuvant treatment could contribute to refine selection of patients who might benefit from a delayed- or no-surgery approach. The aim of this study was to explore the association of clinical and molecular characteristics of rectal cancer with response to neoadjuvant treatment and to compare patient survival according to level of response.Resected rectal cancer patients were selected from a population-based cohort study. Molecular tumor markers were determined from the surgical specimen. Tumor response and pCR were defined as downstaging in T or N stage and absence of tumor cells upon pathological examination, respectively. The associations of patient and tumor characteristics with tumor response and pCR were explored, and patient survival was determined by degree of response to neoadjuvant treatment.Among 1536 patients with rectal cancer, 602 (39
LB  - PUB:(DE-HGF)16
C6  - pmid:32949260
DO  - DOI:10.1007/s00384-020-03744-2
UR  - https://inrepo02.dkfz.de/record/163223
ER  -