TY  - JOUR
AU  - Zheng, Guoqiao
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Försti, Asta
AU  - Hemminki, Akseli
AU  - Hemminki, Kari
TI  - Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor.
JO  - Cancer medicine
VL  - 9
IS  - 21
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2020-01926
SP  - 8258-8265
PY  - 2020
N1  - #EA:C050#LA:C050#LA:C020#                    / 2020 Nov;9(21):8258-8265
AB  - Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC.We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) that are known to be related to immune suppression. We assessed relative risks (RRs) for any of these as concordant (same first and second cancer) and discordant FPC-SPC pairs. Hierarchical clustering of significant RRs was performed for cancers as FPC and SPC.Concordant risks for SPCs were excessive in men and women for nasal (RRs 59.3 for men and 150.6 for women), tongue/mouth (51.7 and 100.8), and lip (32.4 and 61.2) cancers. Heatmaps showed that some cancers, such as skin cancer, tongue/mouth cancers, and non-Hodgkin lymphoma had multiple bidirectional associations as FPC and SPC. Nasal cancer and chronic lymphocytic leukemia had associations mainly as FPC while liver and kidney cancers showed most associations as SPC.Immune dysfunction may be a plausible contributing factor for most of the associations, which calls for experimental verification.
LB  - PUB:(DE-HGF)16
C6  - pmid:32960498
DO  - DOI:10.1002/cam4.3454
UR  - https://inrepo02.dkfz.de/record/163648
ER  -