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000163650 0247_ $$2ISSN$$a1573-7284
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000163650 041__ $$aeng
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000163650 1001_ $$00000-0003-0637-1534$$aModugno, Francesmary$$b0
000163650 245__ $$aOffspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.
000163650 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2020
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000163650 500__ $$a2020 Nov;35(11):1025-1042
000163650 520__ $$aWhile childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among parous participants from 12 case-controls studies comprising 6872 EOC patients and 9101 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case-control associations and polytomous logistic regression for histotype-specific associations, all adjusted for potential confounders. In general, no associations were found between offspring sex and EOC risk. However, compared to bearing only female offspring, bearing one or more male offspring was associated with increased risk of mucinous EOC (OR = 1.45; 95% CI = 1.01-2.07), which appeared to be limited to women reporting menarche before age 13 compared to later menarche (OR = 1.71 vs 0.99; P-interaction = 0.02). Bearing increasing numbers of male offspring was associated with greater risks of mucinous tumors (OR = 1.31, 1.84, 2.31, for 1, 2 and 3 or more male offspring, respectively; trend-p = 0.005). Stratifying by hormonally-associated conditions suggested that compared to bearing all female offspring, bearing a male offspring was associated with lower risk of endometrioid cancer among women with a history of adult acne, hirsutism, or polycystic ovary syndrome (OR = 0.49, 95% CI = 0.28-0.83) but with higher risk among women without any of those conditions (OR = 1.64 95% CI = 1.14-2.34; P-interaction = 0.003). Offspring sex influences the childbearing-EOC risk relationship for specific histotypes and conditions. These findings support the differing etiologic origins of EOC histotypes and highlight the importance of EOC histotype-specific epidemiologic studies. These findings also suggest the need to better understand how pregnancy affects EOC risk.
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000163650 7001_ $$aFu, Zhuxuan$$b1
000163650 7001_ $$aJordan, Susan J$$b2
000163650 7001_ $$aGroup, Aocs$$b3
000163650 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b4$$udkfz
000163650 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aFortner, Renée T$$b5$$udkfz
000163650 7001_ $$aGoodman, Marc T$$b6
000163650 7001_ $$aMoysich, Kirsten B$$b7
000163650 7001_ $$aSchildkraut, Joellen M$$b8
000163650 7001_ $$aBerchuck, Andrew$$b9
000163650 7001_ $$aBandera, Elisa V$$b10
000163650 7001_ $$aQin, Bo$$b11
000163650 7001_ $$aSutphen, Rebecca$$b12
000163650 7001_ $$aMcLaughlin, John R$$b13
000163650 7001_ $$aMenon, Usha$$b14
000163650 7001_ $$aRamus, Susan J$$b15
000163650 7001_ $$aGayther, Simon A$$b16
000163650 7001_ $$aGentry-Maharaj, Aleksandra$$b17
000163650 7001_ $$aKarpinskyj, Chloe$$b18
000163650 7001_ $$aPearce, Celeste L$$b19
000163650 7001_ $$aWu, Anna H$$b20
000163650 7001_ $$aRisch, Harvey A$$b21
000163650 7001_ $$aWebb, Penelope M$$b22
000163650 773__ $$0PERI:(DE-600)2004992-4$$a10.1007/s10654-020-00682-9$$n11$$p1025-1042$$tEuropean journal of epidemiology$$v35$$x1573-7284$$y2020
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