000163651 001__ 163651
000163651 005__ 20240229123154.0
000163651 0247_ $$2doi$$a10.1038/s41467-020-18514-5
000163651 0247_ $$2pmid$$apmid:32958755
000163651 0247_ $$2altmetric$$aaltmetric:90841104
000163651 037__ $$aDKFZ-2020-01929
000163651 041__ $$aeng
000163651 082__ $$a500
000163651 1001_ $$00000-0002-5470-4973$$aBallhausen, Alexej$$b0$$eFirst author
000163651 245__ $$aThe shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.
000163651 260__ $$a[London]$$bNature Publishing Group UK$$c2020
000163651 3367_ $$2DRIVER$$aarticle
000163651 3367_ $$2DataCite$$aOutput Types/Journal article
000163651 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634822034_5773
000163651 3367_ $$2BibTeX$$aARTICLE
000163651 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000163651 3367_ $$00$$2EndNote$$aJournal Article
000163651 500__ $$a#EA:F210#LA:F210#
000163651 520__ $$aThe immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool to quantify frameshift mutations in MSI colorectal and endometrial cancer. Our results show that frameshift mutation frequency is negatively correlated to the predicted immunogenicity of the resulting peptides, suggesting counterselection of cell clones with highly immunogenic frameshift peptides. This correlation is absent in tumors with Beta-2-microglobulin mutations, and HLA-A*02:01 status is related to cMS mutation patterns. Importantly, certain outlier mutations are common in MSI cancers despite being related to frameshift peptides with functionally confirmed immunogenicity, suggesting a possible driver role during MSI tumor evolution. Neoantigens resulting from shared mutations represent promising vaccine candidates for prevention of MSI cancers.
000163651 536__ $$0G:(DE-HGF)POF3-316$$a316 - Infections and cancer (POF3-316)$$cPOF3-316$$fPOF III$$x0
000163651 588__ $$aDataset connected to CrossRef, PubMed,
000163651 7001_ $$0P:(DE-He78)2c6d4f81ba6891f170d25801c181ace1$$aPrzybilla, Moritz Jakob$$b1$$eFirst author
000163651 7001_ $$0P:(DE-HGF)0$$aJendrusch, Michael$$b2$$eFirst author
000163651 7001_ $$00000-0001-7537-9439$$aHaupt, Saskia$$b3
000163651 7001_ $$0P:(DE-HGF)0$$aPfaffendorf, Elisabeth$$b4
000163651 7001_ $$0P:(DE-He78)42ccf6cd47fe67a45f6c7ba82ef71cb4$$aSeidler, Florian$$b5
000163651 7001_ $$0P:(DE-HGF)0$$aWitt, Johannes$$b6
000163651 7001_ $$0P:(DE-He78)ae2b0ea140ce90582429c65ca3f07ddf$$aHernandez Sanchez, Alejandro$$b7
000163651 7001_ $$0P:(DE-He78)9cafc6ecff7e1f32c9d4644c841740cb$$aUrban, Katharina$$b8
000163651 7001_ $$0P:(DE-He78)8f193082367ba9aa5c54634703b1864f$$aDraxlbauer, Markus$$b9
000163651 7001_ $$0P:(DE-He78)6e11760c6fdd0c35cd056cf36243ecd5$$aKrausert, Sonja$$b10
000163651 7001_ $$0P:(DE-He78)07eef6d38a91f4642c810745c5bf5000$$aAhadova, Aysel$$b11
000163651 7001_ $$0P:(DE-He78)f56b635d86a04c198398be3a2ba9e561$$aKalteis, Martin Simon$$b12
000163651 7001_ $$0P:(DE-He78)d5d04ce2423a9de1689951cf098cd32c$$aPfuderer, Pauline$$b13
000163651 7001_ $$0P:(DE-HGF)0$$aHeid, Daniel$$b14
000163651 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b15
000163651 7001_ $$0P:(DE-He78)c826cd3421c6d05725b35568f80b4c67$$aGebert, Johannes$$b16
000163651 7001_ $$0P:(DE-He78)ec22a465429f245d6ef43a2329223262$$aBonsack, Maria$$b17
000163651 7001_ $$aSchott, Sarah$$b18
000163651 7001_ $$aBläker, Hendrik$$b19
000163651 7001_ $$00000-0002-4940-3498$$aSeppälä, Toni$$b20
000163651 7001_ $$aMecklin, Jukka-Pekka$$b21
000163651 7001_ $$aTen Broeke, Sanne$$b22
000163651 7001_ $$aNielsen, Maartje$$b23
000163651 7001_ $$00000-0002-2217-7558$$aHeuveline, Vincent$$b24
000163651 7001_ $$0P:(DE-He78)5a7a75d1b29b770f98f1bb2062fc3df9$$aKrzykalla, Julia$$b25
000163651 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b26
000163651 7001_ $$0P:(DE-He78)3743a1b712edca2ffa829b7096d7037e$$aRiemer, Angelika$$b27
000163651 7001_ $$0P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f$$avon Knebel Doeberitz, Magnus$$b28
000163651 7001_ $$0P:(DE-He78)028ee60cca729028708496826f077b58$$aKloor, Matthias$$b29$$eLast author
000163651 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-18514-5$$gVol. 11, no. 1, p. 4740$$n1$$p4740$$tNature Communications$$v11$$x2041-1723$$y2020
000163651 909CO $$ooai:inrepo02.dkfz.de:163651$$pVDB
000163651 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-5470-4973$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2c6d4f81ba6891f170d25801c181ace1$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)42ccf6cd47fe67a45f6c7ba82ef71cb4$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ae2b0ea140ce90582429c65ca3f07ddf$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9cafc6ecff7e1f32c9d4644c841740cb$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8f193082367ba9aa5c54634703b1864f$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6e11760c6fdd0c35cd056cf36243ecd5$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)07eef6d38a91f4642c810745c5bf5000$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f56b635d86a04c198398be3a2ba9e561$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d5d04ce2423a9de1689951cf098cd32c$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c826cd3421c6d05725b35568f80b4c67$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ec22a465429f245d6ef43a2329223262$$aDeutsches Krebsforschungszentrum$$b17$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5a7a75d1b29b770f98f1bb2062fc3df9$$aDeutsches Krebsforschungszentrum$$b25$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aDeutsches Krebsforschungszentrum$$b26$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3743a1b712edca2ffa829b7096d7037e$$aDeutsches Krebsforschungszentrum$$b27$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000163651 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)028ee60cca729028708496826f077b58$$aDeutsches Krebsforschungszentrum$$b29$$kDKFZ
000163651 9131_ $$0G:(DE-HGF)POF3-316$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vInfections and cancer$$x0
000163651 9141_ $$y2020
000163651 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2018$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2020-01-16
000163651 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2018$$d2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$f2020-01-16
000163651 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-01-16
000163651 9201_ $$0I:(DE-He78)F210-20160331$$kF210$$lAngewandte Tumorbiologie$$x0
000163651 9201_ $$0I:(DE-He78)B300-20160331$$kB300$$lKKE Neuropathologie$$x1
000163651 9201_ $$0I:(DE-He78)F130-20160331$$kF130$$lF130 Immuntherapie und -prävention$$x2
000163651 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lC060 Biostatistik$$x3
000163651 980__ $$ajournal
000163651 980__ $$aVDB
000163651 980__ $$aI:(DE-He78)F210-20160331
000163651 980__ $$aI:(DE-He78)B300-20160331
000163651 980__ $$aI:(DE-He78)F130-20160331
000163651 980__ $$aI:(DE-He78)C060-20160331
000163651 980__ $$aUNRESTRICTED