% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ballhausen:163651,
      author       = {A. Ballhausen$^*$ and M. J. Przybilla$^*$ and M.
                      Jendrusch$^*$ and S. Haupt and E. Pfaffendorf$^*$ and F.
                      Seidler$^*$ and J. Witt$^*$ and A. Hernandez Sanchez$^*$ and
                      K. Urban$^*$ and M. Draxlbauer$^*$ and S. Krausert$^*$ and
                      A. Ahadova$^*$ and M. S. Kalteis$^*$ and P. Pfuderer$^*$ and
                      D. Heid$^*$ and D. Stichel$^*$ and J. Gebert$^*$ and M.
                      Bonsack$^*$ and S. Schott and H. Bläker and T. Seppälä
                      and J.-P. Mecklin and S. Ten Broeke and M. Nielsen and V.
                      Heuveline and J. Krzykalla$^*$ and A. Benner$^*$ and A.
                      Riemer$^*$ and M. von Knebel Doeberitz$^*$ and M. Kloor$^*$},
      title        = {{T}he shared frameshift mutation landscape of
                      microsatellite-unstable cancers suggests immunoediting
                      during tumor evolution.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-01929},
      pages        = {4740},
      year         = {2020},
      note         = {#EA:F210#LA:F210#},
      abstract     = {The immune system can recognize and attack cancer cells,
                      especially those with a high load of mutation-induced
                      neoantigens. Such neoantigens are abundant in DNA mismatch
                      repair (MMR)-deficient, microsatellite-unstable (MSI)
                      cancers. MMR deficiency leads to insertion/deletion (indel)
                      mutations at coding microsatellites (cMS) and to
                      neoantigen-inducing translational frameshifts. Here, we
                      develop a tool to quantify frameshift mutations in MSI
                      colorectal and endometrial cancer. Our results show that
                      frameshift mutation frequency is negatively correlated to
                      the predicted immunogenicity of the resulting peptides,
                      suggesting counterselection of cell clones with highly
                      immunogenic frameshift peptides. This correlation is absent
                      in tumors with Beta-2-microglobulin mutations, and
                      HLA-A*02:01 status is related to cMS mutation patterns.
                      Importantly, certain outlier mutations are common in MSI
                      cancers despite being related to frameshift peptides with
                      functionally confirmed immunogenicity, suggesting a possible
                      driver role during MSI tumor evolution. Neoantigens
                      resulting from shared mutations represent promising vaccine
                      candidates for prevention of MSI cancers.},
      cin          = {F210 / B300 / F130 / C060},
      ddc          = {500},
      cid          = {I:(DE-He78)F210-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)F130-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32958755},
      doi          = {10.1038/s41467-020-18514-5},
      url          = {https://inrepo02.dkfz.de/record/163651},
}