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@ARTICLE{Ebert:163659,
      author       = {N. Ebert$^*$ and A. Kensche$^*$ and S. Löck$^*$ and W. W.
                      Hadiwikarta$^*$ and A. Hänsch$^*$ and W. Dörr$^*$ and M.
                      Krause$^*$ and C. Hannig$^*$ and M. Baumann$^*$},
      title        = {{R}esults of a randomized controlled phase {III} trial:
                      efficacy of polyphenol-containing cystus® tea mouthwash
                      solution for the reduction of mucositis in head and neck
                      cancer patients undergoing external beam radiotherapy.},
      journal      = {Strahlentherapie und Onkologie},
      volume       = {197},
      number       = {1},
      issn         = {1439-099X},
      address      = {Heidelberg},
      publisher    = {Springer Medizin},
      reportid     = {DKFZ-2020-01936},
      pages        = {63-73},
      year         = {2021},
      note         = {#EA:E220#LA:E220#2021 Jan;197(1):63-73},
      abstract     = {To determine the effect of Cystus® tea (Naturprodukte Dr.
                      Pandalis GmbH $\&$ Co. KG) as mouthwash compared to sage tea
                      on oral mucositis in patients undergoing radio(chemo)therapy
                      for head and neck cancer.In this randomized, prospective
                      phase III study, 60 head and neck cancer patients with
                      primary or postoperative radio(chemo)therapy were included
                      between 04/2012 and 06/2014. They received either sage or
                      Cystus® tea for daily mouthwash under therapy. Mucositis
                      was scored twice a week following the Radiation Therapy
                      Oncology Group and the European Organization for Research
                      and Treatment Cancer (RTOG/EORTC) scoring system. Dental
                      parameters were also recorded. Statistical evaluation of the
                      primary endpoint was performed using t‑test and log rank
                      test.Data from 57 patients could be evaluated. Patient
                      characteristics showed no significant difference between the
                      two groups (n = 27 sage; n = 30 Cystus®). A total of
                      55 patients received the prescribed dose (60-66 Gy
                      postoperative; 70-76.8 Gy primary). Mucositis grade 3 was
                      observed in 23 patients (n = 11 sage; n = 12 Cystus®)
                      and occurred between day 16 and 50 after start of therapy.
                      There was no significant difference between the two groups
                      in latency (p = 0.75) and frequency (p = 0.85) of the
                      occurrence of mucositis grade 3. The self-assessment of the
                      oral mucosa and the tolerability of the tea also showed no
                      significant differences. Occurrence of dental pathologies
                      appeared to increase over time after radiotherapy.Cystus®
                      and sage tea have a similar effect on the occurrence of
                      radiation-induced mucositis regarding latency and incidence.
                      Cystus® tea mouthwash solution is tolerated well and can be
                      applied in addition to intensive oral care and hygiene along
                      with the application of fluorides.},
      cin          = {DD01 / E220 / M010},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331 / I:(DE-He78)E220-20160331 /
                      I:(DE-He78)M010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32970162},
      doi          = {10.1007/s00066-020-01684-y},
      url          = {https://inrepo02.dkfz.de/record/163659},
}