%0 Journal Article
%A Arnold, Natalie
%A Rehm, Martin
%A Büchele, Gisela
%A Peter, Raphael Simon
%A Brenner, Rolf Erwin
%A Günther, Klaus-Peter
%A Brenner, Hermann
%A Koenig, Wolfgang
%A Rothenbacher, Dietrich
%T Growth Differentiation Factor-15 as a Potent Predictor of Long-Term Mortality among Subjects with Osteoarthritis.
%J Journal of Clinical Medicine
%V 9
%N 10
%@ 2077-0383
%C Basel
%I MDPI
%M DKFZ-2020-02077
%P 3107 
%D 2020
%X Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel stress-responsive cytokine, and long-term all-cause mortality among OA patients.Within the Ulm Osteoarthritis Study, GDF-15 has been measured in the serum of 636 subjects, who underwent hip or knee arthroplasty between 1995 and 1996 (median age 65 years).During a median follow-up of 19.7 years, a total of 402 deaths occurred. GDF-15 was inversely associated with walking distance. Compared to the bottom quartile (Q), subjects within the top quartile of GDF-15 demonstrated a 2.69-fold increased risk of dying (hazard ratio (HR) (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32993054
%R 10.3390/jcm9103107
%U https://inrepo02.dkfz.de/record/163837