TY  - JOUR
AU  - Arnold, Natalie
AU  - Rehm, Martin
AU  - Büchele, Gisela
AU  - Peter, Raphael Simon
AU  - Brenner, Rolf Erwin
AU  - Günther, Klaus-Peter
AU  - Brenner, Hermann
AU  - Koenig, Wolfgang
AU  - Rothenbacher, Dietrich
TI  - Growth Differentiation Factor-15 as a Potent Predictor of Long-Term Mortality among Subjects with Osteoarthritis.
JO  - Journal of Clinical Medicine
VL  - 9
IS  - 10
SN  - 2077-0383
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-02077
SP  - 3107 
PY  - 2020
AB  - Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel stress-responsive cytokine, and long-term all-cause mortality among OA patients.Within the Ulm Osteoarthritis Study, GDF-15 has been measured in the serum of 636 subjects, who underwent hip or knee arthroplasty between 1995 and 1996 (median age 65 years).During a median follow-up of 19.7 years, a total of 402 deaths occurred. GDF-15 was inversely associated with walking distance. Compared to the bottom quartile (Q), subjects within the top quartile of GDF-15 demonstrated a 2.69-fold increased risk of dying (hazard ratio (HR) (95
LB  - PUB:(DE-HGF)16
C6  - pmid:32993054
DO  - DOI:10.3390/jcm9103107
UR  - https://inrepo02.dkfz.de/record/163837
ER  -