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| 001 | 163837 | ||
| 005 | 20240229123157.0 | ||
| 024 | 7 | _ | |a 10.3390/jcm9103107 |2 doi |
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| 100 | 1 | _ | |a Arnold, Natalie |b 0 |
| 245 | _ | _ | |a Growth Differentiation Factor-15 as a Potent Predictor of Long-Term Mortality among Subjects with Osteoarthritis. |
| 260 | _ | _ | |a Basel |c 2020 |b MDPI |
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| 520 | _ | _ | |a Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel stress-responsive cytokine, and long-term all-cause mortality among OA patients.Within the Ulm Osteoarthritis Study, GDF-15 has been measured in the serum of 636 subjects, who underwent hip or knee arthroplasty between 1995 and 1996 (median age 65 years).During a median follow-up of 19.7 years, a total of 402 deaths occurred. GDF-15 was inversely associated with walking distance. Compared to the bottom quartile (Q), subjects within the top quartile of GDF-15 demonstrated a 2.69-fold increased risk of dying (hazard ratio (HR) (95% confidence interval (CI)) 2.69 (1.82-3.96) adjusted for age, sex, BMI, smoking status, localization of OA, diabetes, maximum walking distance, total cholesterol, and cystatin C. Further adjustment for NT-proBNP, troponin I, and hs-C-reactive protein did not change the results appreciably (HR (95%CI) 1.56 (1.07-2.28); 1.75 (1.21-2.55); 2.32 (1.55-3.47) for Q2, Q3, and Q4 respectively, p for trend < 0.001).In subjects with OA, GDF-15 represents a potent predictor of decreased survival over >20 years, independently of conventional CV risk factors, renal, cardiac, and inflammatory biomarkers as well as walking disability, previously associated with increased mortality and lower extremity OA. |
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| 700 | 1 | _ | |a Rehm, Martin |b 1 |
| 700 | 1 | _ | |a Büchele, Gisela |b 2 |
| 700 | 1 | _ | |a Peter, Raphael Simon |0 0000-0003-4310-9500 |b 3 |
| 700 | 1 | _ | |a Brenner, Rolf Erwin |b 4 |
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| 700 | 1 | _ | |a Rothenbacher, Dietrich |0 0000-0002-3563-2791 |b 8 |
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