%0 Journal Article
%A Neumeyer, Sonja
%A Hua, Xinwei
%A Seibold, Petra
%A Jansen, Lina
%A Benner, Axel
%A Burwinkel, Barbara
%A Halama, Niels
%A Berndt, Sonja I.
%A Phipps, Amanda I.
%A Sakoda, Lori C.
%A Schoen, Robert E
%A Slattery, Martha L.
%A Chan, Andrew T.
%A Gala, Manish
%A Joshi, Amit D.
%A Ogino, Shuji
%A Song, Mingyang
%A Herpel, Esther
%A Bläker, Hendrik
%A Kloor, Matthias
%A Scherer, Dominique
%A Ulrich, Alexis
%A Ulrich, Cornelia M
%A Win, Aung K
%A Figueiredo, Jane C.
%A Hopper, John L.
%A Macrae, Finlay
%A Milne, Roger L
%A Giles, Graham G.
%A Buchanan, Daniel D.
%A Peters, Ulrike
%A Hoffmeister, Michael
%A Brenner, Hermann
%A Newcomb, Polly A.
%A Chang-Claude, Jenny
%T Genetic variants in the regulatory T cell related pathway and colorectal cancer prognosis
%J Cancer epidemiology, biomarkers & prevention
%V 29
%N 12
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2020-02096
%P 2719-2728
%D 2020
%Z 2020 Dec;29(12):2719-2728#EA:C020#LA:C020#
%X Background: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer (CRC) survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer and therefore variants in genes related to Treg differentiation and function could be associated with CRC prognosis.Methods: In a prospective German cohort of 3 593 CRC patients, we assessed the association of 771 SNPs in 58 T-reg related genes with overall and CRC-specific survival using Cox regression models. Effect modification by microsatellite instability (MSI) status was also investigated since tumors with MSI show greater lymphocytic infiltration and have been associated with better prognosis. Replication of significant results was attempted in 2 047 CRC patients of the International Survival Analysis in Colorectal cancer Consortium (ISACC).Results: A significant association of the TGFBR3 SNP rs7524066 with more favorable CRC-specific survival (hazard ratio (HR) per minor allele: 0.83, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33008876
%R 10.1158/1055-9965.EPI-20-0714
%U https://inrepo02.dkfz.de/record/163862