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@ARTICLE{Rhle:163868,
      author       = {A. Rühle$^*$ and S. Rothhaar and E. Haehl$^*$ and T.
                      Kalckreuth$^*$ and T. Sprave$^*$ and R. Stoian$^*$ and C.
                      Zamboglou$^*$ and E. Gkika$^*$ and A. Knopf and A.-L.
                      Grosu$^*$ and N. Nicolay$^*$},
      title        = {{R}adiation-induced toxicities and outcomes after
                      radiotherapy are independent of patient age in elderly
                      salivary gland cancer patients: results from a matched-pair
                      analysis of a rare disease.},
      journal      = {European archives of oto-rhino-laryngology and head $\&$
                      neck},
      volume       = {278},
      number       = {7},
      issn         = {1434-4726},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-02102},
      pages        = {2537-2548},
      year         = {2021},
      note         = {2021 Jul;278(7):2537-2548},
      abstract     = {This study analyzed survival and toxicity after
                      (chemo)radiotherapy for primary salivary gland cancer
                      patients aged ≥ 65 years and compared these results with
                      younger patients using a matched-pair analysis.Twenty-nine
                      elderly patients with primary salivary gland carcinomas
                      treated with (chemo)radiotherapy from 2008 to 2020 at
                      University of Freiburg Medical Center were analyzed for
                      oncological outcomes and therapy-associated toxicities.
                      Local/locoregional control (LRC), progression-free survival
                      (PFS) and overall survival (OS) were calculated using the
                      Kaplan-Meier method, and the influence of clinical
                      parameters on patient outcomes was assessed. A matched-pair
                      analysis was performed after matching with patients <
                      65 years.Nine patients $(31.0\%)$ received definitive
                      (chemo)radiotherapy, and 20 patients $(69.0\%)$ were treated
                      in the adjuvant setting. 2-year LRC, PFS and OS ranged at
                      $82.4\%,$ $53.7\%$ and $71.8\%,$ respectively. Smoking (HR
                      3.980, p = 0.020), reduced performance status (HR 3.735, p =
                      0.016) and higher comorbidity burden (HR 4.601, p = 0.005)
                      correlated with inferior OS. Using a matched-pair analysis
                      with younger patients, elderly patients exhibited a trend
                      towards reduced OS (HR 3.015, p = 0.065), but not PFS (HR
                      1.474, p = 0.371) or LRC (HR 1.324, p = 0.633). Acute and
                      chronic grade 3 toxicities occurred in $31.0\%$ and $12.5\%$
                      of elderly patients, respectively, and the matched-pair
                      analysis revealed no significant differences between age
                      groups regarding treatment-related
                      toxicities.Treatment-related toxicities as well as LRC and
                      PFS were comparable for salivary gland cancer patients
                      undergoing radiotherapy. Therefore, concerns for more
                      pronounced toxicities or reduced local/locoregional response
                      rates should not guide treatment decisions in affected
                      elderly patients.},
      cin          = {FR01 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33000299},
      doi          = {10.1007/s00405-020-06393-x},
      url          = {https://inrepo02.dkfz.de/record/163868},
}