%0 Journal Article
%A Dashti, S Ghazaleh
%A English, Dallas R
%A Simpson, Julie A
%A Karahalios, Amalia
%A Moreno-Betancur, Margarita
%A Biessy, Carine
%A Rinaldi, Sabina
%A Ferrari, Pietro
%A Tjonneland, Anne
%A Halkjær, Jytte
%A Dahm, Christina C
%A Vistisen, Helene Tilma
%A Menegaux, Florence
%A Perduca, Vittorio
%A Severi, Gianluca
%A Aleksandrova, Krasimira
%A Schulze, Matthias B
%A Masala, Giovanna
%A Sieri, Sabina
%A Tumino, Rosario
%A Macciotta, Alessandra
%A Panico, Salvatore
%A Hiensch, Anouk E
%A May, Anne M
%A Quirós, J Ramón
%A Agudo, Antonio
%A Sánchez, Maria-Jose
%A Amiano, Pilar
%A Colorado-Yohar, Sandra
%A Ardanaz, Eva
%A Allen, Naomi E
%A Weiderpass, Elisabete
%A Turzanski-Fortner, Renée
%A Christakoudi, Sofia
%A Tsilidis, Konstantinos K
%A Riboli, Elio
%A Kaaks, Rudolf
%A Gunter, Marc J
%A Viallon, Vivian
%A Dossus, Laure
%T Adiposity and endometrial cancer risk in postmenopausal women: a sequential causal mediation analysis.
%J Cancer epidemiology, biomarkers & prevention
%V 30
%N 1
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2020-02113
%P 104-113
%D 2021
%Z 2021 Jan;30(1):104-113
%X Background Adiposity increases endometrial cancer (EC) risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens. We aimed to quantify the mediating effects of adiponectin (anti-inflammatory adipocytokine); interleukin-6, interleukin-1-receptor antagonist, TNF-receptor-1 and -2, and C-reactive protein (inflammatory status biomarkers); C-peptide (hyperinsulinemia biomarker); free estradiol and estrone (estrogen biomarkers) in the adiposity-EC link in postmenopausal women. Methods We used data from a case-control study within the European Prospective Investigation into Cancer and Nutrition. Eligible women had not had cancer, hysterectomy, diabetes, did not use oral contraceptives or hormone therapy, and were postmenopausal at recruitment. Mediating pathways from adiposity to EC were investigated by estimating natural indirect (NIE) and direct (NDE) effects using sequential mediation analysis. Results The study included 163 cases and 306 controls. The adjusted odds ratio (OR) for EC for BMI≥30vs.18.5≤BMI<25kg/m2 was 2.51 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33008875
%R 10.1158/1055-9965.EPI-20-0965
%U https://inrepo02.dkfz.de/record/163879