TY  - JOUR
AU  - Dashti, S Ghazaleh
AU  - English, Dallas R
AU  - Simpson, Julie A
AU  - Karahalios, Amalia
AU  - Moreno-Betancur, Margarita
AU  - Biessy, Carine
AU  - Rinaldi, Sabina
AU  - Ferrari, Pietro
AU  - Tjonneland, Anne
AU  - Halkjær, Jytte
AU  - Dahm, Christina C
AU  - Vistisen, Helene Tilma
AU  - Menegaux, Florence
AU  - Perduca, Vittorio
AU  - Severi, Gianluca
AU  - Aleksandrova, Krasimira
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Sieri, Sabina
AU  - Tumino, Rosario
AU  - Macciotta, Alessandra
AU  - Panico, Salvatore
AU  - Hiensch, Anouk E
AU  - May, Anne M
AU  - Quirós, J Ramón
AU  - Agudo, Antonio
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra
AU  - Ardanaz, Eva
AU  - Allen, Naomi E
AU  - Weiderpass, Elisabete
AU  - Turzanski-Fortner, Renée
AU  - Christakoudi, Sofia
AU  - Tsilidis, Konstantinos K
AU  - Riboli, Elio
AU  - Kaaks, Rudolf
AU  - Gunter, Marc J
AU  - Viallon, Vivian
AU  - Dossus, Laure
TI  - Adiposity and endometrial cancer risk in postmenopausal women: a sequential causal mediation analysis.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 30
IS  - 1
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-02113
SP  - 104-113
PY  - 2021
N1  - 2021 Jan;30(1):104-113
AB  - Background Adiposity increases endometrial cancer (EC) risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens. We aimed to quantify the mediating effects of adiponectin (anti-inflammatory adipocytokine); interleukin-6, interleukin-1-receptor antagonist, TNF-receptor-1 and -2, and C-reactive protein (inflammatory status biomarkers); C-peptide (hyperinsulinemia biomarker); free estradiol and estrone (estrogen biomarkers) in the adiposity-EC link in postmenopausal women. Methods We used data from a case-control study within the European Prospective Investigation into Cancer and Nutrition. Eligible women had not had cancer, hysterectomy, diabetes, did not use oral contraceptives or hormone therapy, and were postmenopausal at recruitment. Mediating pathways from adiposity to EC were investigated by estimating natural indirect (NIE) and direct (NDE) effects using sequential mediation analysis. Results The study included 163 cases and 306 controls. The adjusted odds ratio (OR) for EC for BMI≥30vs.18.5≤BMI<25kg/m2 was 2.51 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:33008875
DO  - DOI:10.1158/1055-9965.EPI-20-0965
UR  - https://inrepo02.dkfz.de/record/163879
ER  -