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@ARTICLE{Doege:163926,
      author       = {D. Doege$^*$ and M. Thong$^*$ and L. Koch-Gallenkamp$^*$
                      and L. Jansen$^*$ and H. Bertram and A. Eberle and B.
                      Holleczek and R. Pritzkuleit and A. Waldmann and S. R.
                      Zeissig and H. Brenner$^*$ and V. Arndt$^*$},
      title        = {{A}ge-specific prevalence and determinants of depression in
                      long-term breast cancer survivors compared to female
                      population controls.},
      journal      = {Cancer medicine},
      volume       = {9},
      number       = {22},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2020-02150},
      pages        = {8713-8721},
      year         = {2020},
      note         = {#EA:C071#LA:C071#2020 Nov;9(22):8713-8721},
      abstract     = {Depression is more prevalent in breast cancer (BC)
                      survivors than in the general population. However, little is
                      known about depression in long-term survivors. Study
                      objectives were: (1) to compare the age-specific prevalence
                      of depressive symptoms (a) in BC survivors vs female
                      population controls, (b) in disease-free BC survivors vs BC
                      survivors with self-reported recurrence vs controls, and (2)
                      to explore determinants of depression in BC survivors.About
                      3010 BC survivors (stage I-III, 5-16 years post-diagnosis),
                      and 1005 population controls were recruited in German
                      multi-regional population-based studies. Depression was
                      assessed by the Geriatric Depression Scale-15. Prevalence of
                      mild/severe and severe depression only were estimated via
                      logistic regression, controlling for age and education.
                      Multinomial logistic regression was used to explore
                      determinants of mild and severe depression.Compared with
                      population controls, BC survivors were more likely to report
                      mild/severe depression $(30.4\%$ vs $23.8\%,$ p = .0003),
                      adjusted for age and education. At all age groups
                      <80 years, prevalence of both mild/severe and severe
                      depression only was significantly higher in BC survivors,
                      while BC survivors ≥80 years reported severe depression
                      less frequently than controls. BC survivors with recurrence
                      reported significantly higher prevalence of mild/severe
                      depression than disease-free survivors and controls, but
                      prevalence in disease-free survivors and controls was
                      comparable. Age, income, living independently, recurrence,
                      and BMI were significant determinants of mild depression in
                      BC survivors. Age, education, employment, income,
                      recurrence, and BMI were significant determinants of severe
                      depression.Long-term BC survivors <80 years report
                      significantly higher prevalence of depressive symptoms than
                      controls, which might be explained by recurrence and
                      individual factors. The findings suggest that depression in
                      BC survivors is common, and even more after BC recurrence.
                      Clinicians should routinize screening and normalize referral
                      to psychological care.},
      cin          = {C071 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33022889},
      doi          = {10.1002/cam4.3476},
      url          = {https://inrepo02.dkfz.de/record/163926},
}