% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Siziba:163981,
      author       = {L. P. Siziba and L. Lorenz and H. Brenner$^*$ and P.
                      Carr$^*$ and B. Stahl and M. Mank and T. Marosvölgyi and T.
                      Decsi and E. Szabo and D. Rothenbacher and J. Genuneit},
      title        = {{C}hanges in human milk fatty acid composition and maternal
                      lifestyle-related factors over a decade: a comparison
                      between the two {U}lm {B}irth {C}ohort {S}tudies.},
      journal      = {British journal of nutrition},
      volume       = {126},
      number       = {2},
      issn         = {1475-2662},
      address      = {Cambridge},
      publisher    = {Cambridge Univ. Press},
      reportid     = {DKFZ-2020-02189},
      pages        = {228-235},
      year         = {2021},
      note         = {2021 Jul 28;126(2):228-235},
      abstract     = {Human milk fatty acid composition varies during lactation
                      and is influenced by maternal diet, maternal
                      lifestyle-related factors and genetic background. This is
                      one of the first studies to investigate a period effect,
                      i.e. the impact of lifestyle-related changes on human milk
                      fatty acid composition, in two different cohorts. Lactating
                      women were recruited from the general population a decade
                      apart in Ulm, Germany, using similar methodology. Human milk
                      samples collected 6 weeks post-partum were analysed [Ulm
                      Birth Cohort Study (UBCS (2000)), n=567; Ulm SPATZ Health
                      Study (SPATZ (2012)), n=458)]. Centred log ratio
                      transformation was applied to fatty acid data. Principal
                      component analysis (PCA) was used to determine
                      study-dependent fatty acid profiles. A general linear model
                      was used to determine the study (or period) effect on fatty
                      acid profiles adjusting for duration of gestation, age,
                      education, delivery mode, smoking and pre-pregnancy BMI. Two
                      principal components were retained (PC1 and PC2). PC1 was
                      associated with UBCS, while PC2 was associated with SPATZ.
                      PC1 comprised high saturated fatty acids (SFAs), and low
                      monounsaturated fatty acids (MUFAs), n-6 and n-3 long-chain
                      polyunsaturated fatty acids (LCPUFAs). The inverse was true
                      for PC2. Although human milk remains a source of essential
                      fatty acids, infants could be at risk of inadequate n-3 and
                      n-6 LCPUFA intake through human milk. The differences in the
                      human milk fatty acid profiles also reflect changes in
                      maternal dietary habits in the more recent cohort, which may
                      comprise lower intakes of dietary TFAs, SFAs and higher
                      intakes of vegetable oils.},
      cin          = {C070},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33040757},
      doi          = {10.1017/S0007114520004006},
      url          = {https://inrepo02.dkfz.de/record/163981},
}