%0 Journal Article
%A Gerhalter, Teresa
%A Marty, Benjamin
%A Gast, Lena V
%A Porzelt, Katharina
%A Heiss, Rafael
%A Uder, Michael
%A Schwab, Stefan
%A Carlier, Pierre G
%A Nagel, Armin
%A Türk, Matthias
%T Quantitative 1H and 23Na muscle MRI in Facioscapulohumeral muscular dystrophy patients.
%J Journal of neurology
%V 268
%N 3
%@ 0340-5354
%C Berlin
%I Springer59671
%M DKFZ-2020-02196
%P 1076-1087
%D 2021
%Z 2021 Mar;268(3):1076-1087
%X Our aim was to assess the role of quantitative 1H and 23Na MRI methods in providing imaging biomarkers of disease activity and severity in patients with Facioscapulohumeral muscular dystrophy (FSHD).We imaged the lower leg muscles of 19 FSHD patients and 12 controls with a multimodal MRI protocol to obtain STIR-T2w images, fat fraction (FF), water T2 (wT2), water T1 (wT1), tissue sodium concentration (TSC), and intracellular-weighted sodium signal (inversion recovery (IR) and triple quantum filter (TQF) sequence). In addition, the FSHD patients underwent muscle strength testing.Imaging biomarkers related with water mobility (wT1 and wT2) and ion homeostasis (TSC, IR, TQF) were increased in muscles of FSHD patients. Muscle groups with FF > 10
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33047224
%R 10.1007/s00415-020-10254-2
%U https://inrepo02.dkfz.de/record/163996