TY  - JOUR
AU  - Gerhalter, Teresa
AU  - Marty, Benjamin
AU  - Gast, Lena V
AU  - Porzelt, Katharina
AU  - Heiss, Rafael
AU  - Uder, Michael
AU  - Schwab, Stefan
AU  - Carlier, Pierre G
AU  - Nagel, Armin
AU  - Türk, Matthias
TI  - Quantitative 1H and 23Na muscle MRI in Facioscapulohumeral muscular dystrophy patients.
JO  - Journal of neurology
VL  - 268
IS  - 3
SN  - 0340-5354
CY  - Berlin
PB  - Springer59671
M1  - DKFZ-2020-02196
SP  - 1076-1087
PY  - 2021
N1  - 2021 Mar;268(3):1076-1087
AB  - Our aim was to assess the role of quantitative 1H and 23Na MRI methods in providing imaging biomarkers of disease activity and severity in patients with Facioscapulohumeral muscular dystrophy (FSHD).We imaged the lower leg muscles of 19 FSHD patients and 12 controls with a multimodal MRI protocol to obtain STIR-T2w images, fat fraction (FF), water T2 (wT2), water T1 (wT1), tissue sodium concentration (TSC), and intracellular-weighted sodium signal (inversion recovery (IR) and triple quantum filter (TQF) sequence). In addition, the FSHD patients underwent muscle strength testing.Imaging biomarkers related with water mobility (wT1 and wT2) and ion homeostasis (TSC, IR, TQF) were increased in muscles of FSHD patients. Muscle groups with FF > 10
LB  - PUB:(DE-HGF)16
C6  - pmid:33047224
DO  - DOI:10.1007/s00415-020-10254-2
UR  - https://inrepo02.dkfz.de/record/163996
ER  -