% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Gerhalter:163996,
      author       = {T. Gerhalter and B. Marty and L. V. Gast and K. Porzelt and
                      R. Heiss and M. Uder and S. Schwab and P. G. Carlier and A.
                      Nagel$^*$ and M. Türk},
      title        = {{Q}uantitative 1{H} and 23{N}a muscle {MRI} in
                      {F}acioscapulohumeral muscular dystrophy patients.},
      journal      = {Journal of neurology},
      volume       = {268},
      number       = {3},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer59671},
      reportid     = {DKFZ-2020-02196},
      pages        = {1076-1087},
      year         = {2021},
      note         = {2021 Mar;268(3):1076-1087},
      abstract     = {Our aim was to assess the role of quantitative 1H and 23Na
                      MRI methods in providing imaging biomarkers of disease
                      activity and severity in patients with Facioscapulohumeral
                      muscular dystrophy (FSHD).We imaged the lower leg muscles of
                      19 FSHD patients and 12 controls with a multimodal MRI
                      protocol to obtain STIR-T2w images, fat fraction (FF), water
                      T2 (wT2), water T1 (wT1), tissue sodium concentration (TSC),
                      and intracellular-weighted sodium signal (inversion recovery
                      (IR) and triple quantum filter (TQF) sequence). In addition,
                      the FSHD patients underwent muscle strength testing.Imaging
                      biomarkers related with water mobility (wT1 and wT2) and ion
                      homeostasis (TSC, IR, TQF) were increased in muscles of FSHD
                      patients. Muscle groups with FF > $10\%$ had higher wT2,
                      wT1, TSC, IR, and TQF values than muscles with FF < $10\%.$
                      Muscles with FF < $10\%$ resembled muscles of healthy
                      controls for these MRI disease activity measures. However,
                      wT1 was increased in few muscles without fat replacement.
                      Furthermore, few STIR-negative muscles (n = 11/76) exhibited
                      increased wT1, TSC, IR or TQF. Increased wT1 as well as 23Na
                      signals were also present in muscles with normal wT2. Muscle
                      strength was related to the mean FF and all imaging
                      biomarkers of tibialis anterior except wT2 were correlated
                      with dorsal flexion.The newly evaluated imaging biomarkers
                      related with water mobility (wT1) and ion homeostasis (TSC,
                      IR, TQF) showed different patterns compared to the
                      established markers like FF in muscles of FSHD patients.
                      These quantitative biomarkers could thus contain valuable
                      complementary information for the early characterization of
                      disease progression.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33047224},
      doi          = {10.1007/s00415-020-10254-2},
      url          = {https://inrepo02.dkfz.de/record/163996},
}