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@ARTICLE{Scherer:164042,
      author       = {S. Scherer$^*$ and L. Jansen$^*$ and D. Boakye$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{C}hanges in health-related outcomes among colorectal
                      cancer patients undergoing inpatient rehabilitation therapy:
                      a systematic review of observational and interventional
                      studies.},
      journal      = {Acta oncologica},
      volume       = {60},
      number       = {1},
      issn         = {0001-6926},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2020-02210},
      pages        = {124-134},
      year         = {2021},
      note         = {#EA:C120#LA:C070#2021 Jan;60(1):124-134},
      abstract     = {Colorectal cancer (CRC) and its treatment can lead to
                      several physical and psychosocial impairments. Cancer
                      rehabilitation aims to reduce morbidity and improve quality
                      of life. The objective of this review was to summarize and
                      evaluate evidence on changes in health-related outcomes
                      among CRC patients undergoing inpatient rehabilitation
                      therapy and on the effectiveness of such treatment.We
                      conducted a systematic literature search including the
                      electronic databases Pubmed and Web of Science to find
                      observational and interventional studies, which investigated
                      changes in health-related outcomes among CRC patients
                      undergoing multidisciplinary inpatient rehabilitation
                      programs or treatment effects. Study findings were
                      synthesized narratively.Eleven studies were eligible and
                      included in this review. Eight patient cohort studies
                      addressed outcomes such as physical and functional status,
                      fecal incontinence, anxiety and depression, and quality of
                      life. Positive changes during rehabilitation therapy were
                      observed for physical health (functional and physical
                      status, fecal incontinence), and several dimensions of
                      quality of life. Study findings concerning anxiety and
                      depression were not conclusive. Studies that additionally
                      conducted long-term follow-ups indicated that the improved
                      health status after rehabilitative treatment waned over
                      time. One RCT reported no effect of inpatient rehabilitation
                      on distress and two randomized trials reported effects of
                      exercise intensity on oxidative stress and immune response.
                      Sample sizes were low (<100 included CRC patients) in eight
                      studies and only the RCT included a comparison group
                      (non-rehabilitants).The scientific evidence level was very
                      limited. Due to the lack of a comparison group in most
                      studies, we were only able to evaluate changes during/after
                      inpatient rehabilitation therapy but not the effectiveness
                      of treatment. However, study findings suggest that physical
                      health and functional independence improve during inpatient
                      rehabilitation, but improvements wane over time. Further
                      large representative studies, in particular RCTs with
                      long-term follow-up, are essential to evaluate the
                      effectiveness of inpatient rehabilitation and identify
                      determinants of treatment success.},
      subtyp        = {Review Article},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33073647},
      doi          = {10.1080/0284186X.2020.1828620},
      url          = {https://inrepo02.dkfz.de/record/164042},
}