TY  - JOUR
AU  - Peters, Susan
AU  - Broberg, Karin
AU  - Gallo, Valentina
AU  - Levi, Michael
AU  - Kippler, Maria
AU  - Vineis, Paolo
AU  - Veldink, Jan
AU  - van den Berg, Leonard
AU  - Middleton, Lefkos
AU  - Travis, Ruth C
AU  - Bergmann, Manuela M
AU  - Palli, Domenico
AU  - Grioni, Sara
AU  - Tumino, Rosario
AU  - Elbaz, Alexis
AU  - Vlaar, Tim
AU  - Mancini, Francesca
AU  - Kühn, Tilman
AU  - Katzke, Verena
AU  - Agudo, Antonio
AU  - Goñi, Fernando
AU  - Gómez, Jesús-Humberto
AU  - Rodríguez-Barranco, Miguel
AU  - Merino, Susana
AU  - Barricarte, Aurelio
AU  - Trichopoulou, Antonia
AU  - Jenab, Mazda
AU  - Weiderpass, Elisabete
AU  - Vermeulen, Roel
TI  - Blood metal levels and amyotrophic lateral sclerosis risk: a prospective cohort.
JO  - Annals of neurology
VL  - 89
IS  - 1
SN  - 1531-8249
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DKFZ-2020-02213
SP  - 125-133
PY  - 2021
N1  - 2021 Jan;89(1):125-133
AB  - Metals have been suggested as risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ALS patients and controls, to explore whether metals are associated with ALS mortality.A nested ALS case-control study was conducted within the prospective EPIC cohort. Cases were identified through death certificates. We analyzed metal levels in erythrocyte samples obtained at recruitment, as biomarker for metal exposure from any source. Arsenic, cadmium, copper, lead, manganese, mercury, selenium and zinc concentrations were measured by inductively coupled plasma-mass spectrometry. To estimate ALS risk, we applied conditional logistic regression models.The study population comprised 107 cases (65
LB  - PUB:(DE-HGF)16
C6  - pmid:33068316
DO  - DOI:10.1002/ana.25932
UR  - https://inrepo02.dkfz.de/record/164045
ER  -