TY  - JOUR
AU  - Zheng, Ju-Sheng
AU  - Luan, Jian'an
AU  - Sofianopoulou, Eleni
AU  - Sharp, Stephen J
AU  - Day, Felix R
AU  - Imamura, Fumiaki
AU  - Gundersen, Thomas E
AU  - Lotta, Luca A
AU  - Sluijs, Ivonne
AU  - Stewart, Isobel D
AU  - Shah, Rupal L
AU  - van der Schouw, Yvonne T
AU  - Wheeler, Eleanor
AU  - Ardanaz, Eva
AU  - Boeing, Heiner
AU  - Dorronsoro, Miren
AU  - Dahm, Christina C
AU  - Dimou, Niki
AU  - El-Fatouhi, Douae
AU  - Franks, Paul W
AU  - Fagherazzi, Guy
AU  - Grioni, Sara
AU  - Huerta, José María
AU  - Heath, Alicia K
AU  - Hansen, Louise
AU  - Jenab, Mazda
AU  - Jakszyn, Paula
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
AU  - Khaw, Kay-Tee
AU  - Laouali, Nasser
AU  - Masala, Giovanna
AU  - Nilsson, Peter M
AU  - Overvad, Kim
AU  - Olsen, Anja
AU  - Panico, Salvatore
AU  - Quirós, J Ramón
AU  - Rolandsson, Olov
AU  - Rodríguez-Barranco, Miguel
AU  - Sacerdote, Carlotta
AU  - Spijkerman, Annemieke M W
AU  - Tong, Tammy Y N
AU  - Tumino, Rosario
AU  - Tsilidis, Konstantinos K
AU  - Danesh, John
AU  - Riboli, Elio
AU  - Butterworth, Adam S
AU  - Langenberg, Claudia
AU  - Forouhi, Nita G
AU  - Wareham, Nicholas J
TI  - The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.
JO  - PLoS medicine
VL  - 17
IS  - 10
SN  - 1549-1676
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2020-02218
SP  - e1003394 -
PY  - 2020
AB  - Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of these associations using Mendelian randomisation (MR) analysis.We performed a meta-analysis of genome-wide association studies for total 25(OH)D (N = 120,618), 25(OH)D3 (N = 40,562), and C3-epi-25(OH)D3 (N = 40,562) in participants of European descent (European Prospective Investigation into Cancer and Nutrition [EPIC]-InterAct study, EPIC-Norfolk study, EPIC-CVD study, Ely study, and the SUNLIGHT consortium). We identified genetic variants for MR analysis to investigate the causal association of the 25(OH)D metabolites with T2D (including 80,983 T2D cases and 842,909 non-cases). We also estimated the observational association of 25(OH)D metabolites with T2D by performing random effects meta-analysis of results from previous studies and results from the EPIC-InterAct study. We identified 10 genetic loci associated with total 25(OH)D, 7 loci associated with 25(OH)D3 and 3 loci associated with C3-epi-25(OH)D3. Based on the meta-analysis of observational studies, each 1-standard deviation (SD) higher level of 25(OH)D was associated with a 20
LB  - PUB:(DE-HGF)16
C6  - pmid:33064751
DO  - DOI:10.1371/journal.pmed.1003394
UR  - https://inrepo02.dkfz.de/record/164050
ER  -