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000164060 1001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b0$$eFirst author$$udkfz
000164060 245__ $$aThe design heatmap: A simple visualization of D -optimality design problems.
000164060 260__ $$aBerlin$$bWiley-VCH$$c2020
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000164060 500__ $$a#EA:C060#LA:C060# / Volume62, Issue 8 December 2020 Pages 2013-2031
000164060 520__ $$aOptimal experimental designs are often formal and specific, and not intuitively plausible to practical experimenters. However, even in theory, there often are many different possible design points providing identical or nearly identical information compared to the design points of a strictly optimal design. In practical applications, this can be used to find designs that are a compromise between mathematical optimality and practical requirements, including preferences of experimenters. For this purpose, we propose a derivative-based two-dimensional graphical representation of the design space that, given any optimal design is already known, will show which areas of the design space are relevant for good designs and how these areas relate to each other. While existing equivalence theorems already allow such an illustration in regard to the relevance of design points only, our approach also shows whether different design points contribute the same kind of information, and thus allows tweaking of designs for practical applications, especially in regard to the splitting and combining of design points. We demonstrate the approach on a toxicological trial where a D -optimal design for a dose-response experiment modeled by a four-parameter log-logistic function was requested. As these designs require a prior estimate of the relevant parameters, which is difficult to obtain in a practical situation, we also discuss an adaption of our representations to the criterion of Bayesian D -optimality. While we focus on D -optimality, the approach is in principle applicable to different optimality criteria as well. However, much of the computational and graphical simplicity will be lost.
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000164060 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b1$$eLast author$$udkfz
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