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@ARTICLE{DiMarco:164063,
      author       = {B. Di Marco$^*$ and E. E. Crouch and B. Shah and C.
                      Duman$^*$ and M. F. Paredes and C. Ruiz de Almodovar and E.
                      J. Huang and J. Alfonso$^*$},
      title        = {{R}eciprocal {I}nteraction between {V}ascular {F}ilopodia
                      and {N}eural {S}tem {C}ells {S}hapes {N}eurogenesis in the
                      {V}entral {T}elencephalon.},
      journal      = {Cell reports},
      volume       = {33},
      number       = {2},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-02231},
      pages        = {108256},
      year         = {2020},
      note         = {#EA:A231#LA:A231#},
      abstract     = {Angiogenesis and neurogenesis are tightly coupled during
                      embryonic brain development. However, little is known about
                      how these two processes interact. We show that nascent blood
                      vessels actively contact dividing neural stem cells by
                      endothelial filopodia in the ventricular zone (VZ) of the
                      murine ventral telencephalon; this association is conserved
                      in the human ventral VZ. Using mouse mutants with altered
                      vascular filopodia density, we show that this interaction
                      leads to prolonged cell cycle of apical neural progenitors
                      (ANPs) and favors early neuronal differentiation.
                      Interestingly, pharmacological experiments reveal that ANPs
                      induce vascular filopodia formation by upregulating vascular
                      endothelial growth factor (VEGF)-A in a cell-cycle-dependent
                      manner. This mutual relationship between vascular filopodia
                      and ANPs works as a self-regulatory system that senses ANP
                      proliferation rates and rapidly adjusts neuronal production
                      levels. Our findings indicate a function of vascular
                      filopodia in fine-tuning neural stem cell behavior, which is
                      the basis for proper brain development.},
      cin          = {A231},
      ddc          = {610},
      cid          = {I:(DE-He78)A231-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33053356},
      doi          = {10.1016/j.celrep.2020.108256},
      url          = {https://inrepo02.dkfz.de/record/164063},
}