%0 Journal Article
%A Aglago, Elom Kouassivi
%A Rinaldi, Sabina
%A Freisling, Heinz
%A Jiao, Li
%A Hughes, David J
%A Fedirko, Veronika
%A Schalkwijk, Casper G
%A Weiderpass, Elisabete
%A Dahm, Christina C
%A Overvad, Kim
%A Eriksen, Anne Kirstine
%A Kyrø, Cecilie
%A Boutron-Ruault, Marie-Christine
%A Rothwell, Joseph A
%A Severi, Gianluca
%A Katzke, Verena
%A Kühn, Tilman
%A Schulze, Matthias B
%A Aleksandrova, Krasimira
%A Masala, Giovanna
%A Krogh, Vittorio
%A Panico, Salvatore
%A Tumino, Rosario
%A Naccarati, Alessio
%A Bueno-de-Mesquita, Bas
%A van Gils, Carla H
%A Sandanger, Torkjel M
%A Gram, Inger T
%A Skeie, Guri
%A Quirós, J Ramón
%A Jakszyn, Paula
%A Sánchez, Maria-Jose
%A Amiano, Pilar
%A Huerta, José María
%A Ardanaz, Eva
%A Johansson, Ingegerd
%A Harlid, Sophia
%A Perez-Cornago, Aurora
%A Mayén, Ana-Lucia
%A Cordova, Reynalda
%A Gunter, Marc J
%A Vineis, Paolo
%A Cross, Amanda J
%A Riboli, Elio
%A Jenab, Mazda
%T Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a case-control study nested within a European prospective cohort.
%J Cancer epidemiology, biomarkers & prevention
%V 30
%N 1
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2020-02242
%P 182-192
%D 2021
%Z 2021 Jan;30(1):182-192
%X Overexpression of the Receptor for Advanced Glycation End-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer (CRC) risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation.To investigate whether sRAGE and related genetic variants are associated with CRC risk, we conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 CRC matched case-control sets. Twenty-four single nucleotide polymorphisms (SNPs) encoded in the genes associated with sRAGE concentrations were available for 1,985 CRC cases and 2,220 controls. Multivariable-adjusted odds ratios (ORs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33082206
%R 10.1158/1055-9965.EPI-20-0855
%U https://inrepo02.dkfz.de/record/164096