TY  - JOUR
AU  - Aglago, Elom Kouassivi
AU  - Rinaldi, Sabina
AU  - Freisling, Heinz
AU  - Jiao, Li
AU  - Hughes, David J
AU  - Fedirko, Veronika
AU  - Schalkwijk, Casper G
AU  - Weiderpass, Elisabete
AU  - Dahm, Christina C
AU  - Overvad, Kim
AU  - Eriksen, Anne Kirstine
AU  - Kyrø, Cecilie
AU  - Boutron-Ruault, Marie-Christine
AU  - Rothwell, Joseph A
AU  - Severi, Gianluca
AU  - Katzke, Verena
AU  - Kühn, Tilman
AU  - Schulze, Matthias B
AU  - Aleksandrova, Krasimira
AU  - Masala, Giovanna
AU  - Krogh, Vittorio
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Naccarati, Alessio
AU  - Bueno-de-Mesquita, Bas
AU  - van Gils, Carla H
AU  - Sandanger, Torkjel M
AU  - Gram, Inger T
AU  - Skeie, Guri
AU  - Quirós, J Ramón
AU  - Jakszyn, Paula
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Huerta, José María
AU  - Ardanaz, Eva
AU  - Johansson, Ingegerd
AU  - Harlid, Sophia
AU  - Perez-Cornago, Aurora
AU  - Mayén, Ana-Lucia
AU  - Cordova, Reynalda
AU  - Gunter, Marc J
AU  - Vineis, Paolo
AU  - Cross, Amanda J
AU  - Riboli, Elio
AU  - Jenab, Mazda
TI  - Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a case-control study nested within a European prospective cohort.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 30
IS  - 1
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-02242
SP  - 182-192
PY  - 2021
N1  - 2021 Jan;30(1):182-192
AB  - Overexpression of the Receptor for Advanced Glycation End-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer (CRC) risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation.To investigate whether sRAGE and related genetic variants are associated with CRC risk, we conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 CRC matched case-control sets. Twenty-four single nucleotide polymorphisms (SNPs) encoded in the genes associated with sRAGE concentrations were available for 1,985 CRC cases and 2,220 controls. Multivariable-adjusted odds ratios (ORs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33082206
DO  - DOI:10.1158/1055-9965.EPI-20-0855
UR  - https://inrepo02.dkfz.de/record/164096
ER  -