TY  - JOUR
AU  - Brenner, Hermann
AU  - Krilaviciute, Agne
TI  - Commonly Applied Selection Criteria for Lung Cancer Screening May Have Strongly Varying Diagnostic Performance in Different Countries.
JO  - Cancers
VL  - 12
IS  - 10
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-02244
SP  - 3012
PY  - 2020
N1  - #EA:C070#LA:C070#
AB  - Lung cancer (LC) screening often focuses heavy smokers as a target for screening group. Heavy smoking can thus be regarded as an LC pre-screening test with sensitivities and specificities being different in various populations due to the differences in smoking histories. We derive here expected sensitivities and specificities of various criteria to preselect individuals for LC screening in 27 European countries with diverse smoking prevalences. Sensitivities of various heavy-smoking-based pre-screening criteria were estimated by combining sex-specific proportions of people meeting these criteria in the target population for screening with associations of heavy smoking with LC risk. Expected specificities were approximated by the proportion of individuals not meeting the heavy smoking definition. Estimated sensitivities and specificities varied widely across countries, with sensitivities being generally higher among men (range: 33-80
LB  - PUB:(DE-HGF)16
C6  - pmid:33081402
DO  - DOI:10.3390/cancers12103012
UR  - https://inrepo02.dkfz.de/record/164098
ER  -