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@ARTICLE{Brenner:164098,
      author       = {H. Brenner$^*$ and A. Krilaviciute$^*$},
      title        = {{C}ommonly {A}pplied {S}election {C}riteria for {L}ung
                      {C}ancer {S}creening {M}ay {H}ave {S}trongly {V}arying
                      {D}iagnostic {P}erformance in {D}ifferent {C}ountries.},
      journal      = {Cancers},
      volume       = {12},
      number       = {10},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-02244},
      pages        = {3012},
      year         = {2020},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Lung cancer (LC) screening often focuses heavy smokers as a
                      target for screening group. Heavy smoking can thus be
                      regarded as an LC pre-screening test with sensitivities and
                      specificities being different in various populations due to
                      the differences in smoking histories. We derive here
                      expected sensitivities and specificities of various criteria
                      to preselect individuals for LC screening in 27 European
                      countries with diverse smoking prevalences. Sensitivities of
                      various heavy-smoking-based pre-screening criteria were
                      estimated by combining sex-specific proportions of people
                      meeting these criteria in the target population for
                      screening with associations of heavy smoking with LC risk.
                      Expected specificities were approximated by the proportion
                      of individuals not meeting the heavy smoking definition.
                      Estimated sensitivities and specificities varied widely
                      across countries, with sensitivities being generally higher
                      among men (range: $33-80\%)$ than among women (range:
                      $9-79\%),$ and specificities being generally lower among men
                      (range: $48-90\%)$ than among women (range: $70-99\%).$
                      Major variation in sensitivities and specificities was also
                      seen across different pre-selection criteria for LC
                      screening within individual countries. Our results may
                      inform the design of LC screening programs in European
                      countries and serve as benchmarks for novel alternative or
                      complementary tests for selecting people at high risk for
                      CT-based LC screening.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33081402},
      doi          = {10.3390/cancers12103012},
      url          = {https://inrepo02.dkfz.de/record/164098},
}