TY  - JOUR
AU  - Hassan, Lamiaa
AU  - Medenwald, Daniel
AU  - Tiller, Daniel
AU  - Kluttig, Alexander
AU  - Ludwig-Kraus, Beatrice
AU  - Kraus, Frank Bernhard
AU  - Greiser, Karin H
AU  - Mikolajczyk, Rafael
TI  - The association between change of soluble tumor necrosis factor receptor R1 (sTNF-R1) measurements and cardiovascular and all-cause mortality-Results from the population-based (Cardiovascular Disease, Living and Ageing in Halle) CARLA study 2002-2016.
JO  - PLOS ONE
VL  - 15
IS  - 10
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DKFZ-2020-02300
SP  - e0241213 -
PY  - 2020
AB  - Single measurements of higher levels of soluble tumor necrosis factor receptor I (sTNF-R1) have been shown to be associated with increased risk of mortality. However, up to date, little is known about the underlying temporal dynamics of sTNF-R1 concentrations and their relation with mortality. We aimed to characterize the effect of changes in sTNFR-1 levels on all-cause and cardiovascular mortality, independent from other established risk factors for mortality, including other inflammatory markers.We used data of the population based cohort study CARLA and included 1408 subjects with sTNF-R1 measured at baseline (2002-2006) and first follow-up (2007-2010). Cox proportional hazard models were used to assess the association of baseline and follow-up sTNF-R1 measurements with all-cause and cardiovascular mortality during  10 years since the first follow-up after adjusting for relevant confounders.Based on 211 deaths among 1408 subjects, per each doubling of the baseline sTNF-R1, the risk of all-cause mortality was increased by about 30
LB  - PUB:(DE-HGF)16
C6  - pmid:33104754
DO  - DOI:10.1371/journal.pone.0241213
UR  - https://inrepo02.dkfz.de/record/164171
ER  -