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@ARTICLE{Hassan:164171,
      author       = {L. Hassan and D. Medenwald and D. Tiller and A. Kluttig and
                      B. Ludwig-Kraus and F. B. Kraus and K. H. Greiser$^*$ and R.
                      Mikolajczyk},
      title        = {{T}he association between change of soluble tumor necrosis
                      factor receptor {R}1 (s{TNF}-{R}1) measurements and
                      cardiovascular and all-cause mortality-{R}esults from the
                      population-based ({C}ardiovascular {D}isease, {L}iving and
                      {A}geing in {H}alle) {CARLA} study 2002-2016.},
      journal      = {PLOS ONE},
      volume       = {15},
      number       = {10},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2020-02300},
      pages        = {e0241213 -},
      year         = {2020},
      abstract     = {Single measurements of higher levels of soluble tumor
                      necrosis factor receptor I (sTNF-R1) have been shown to be
                      associated with increased risk of mortality. However, up to
                      date, little is known about the underlying temporal dynamics
                      of sTNF-R1 concentrations and their relation with mortality.
                      We aimed to characterize the effect of changes in sTNFR-1
                      levels on all-cause and cardiovascular mortality,
                      independent from other established risk factors for
                      mortality, including other inflammatory markers.We used data
                      of the population based cohort study CARLA and included 1408
                      subjects with sTNF-R1 measured at baseline (2002-2006) and
                      first follow-up (2007-2010). Cox proportional hazard models
                      were used to assess the association of baseline and
                      follow-up sTNF-R1 measurements with all-cause and
                      cardiovascular mortality during ~10 years since the first
                      follow-up after adjusting for relevant confounders.Based on
                      211 deaths among 1408 subjects, per each doubling of the
                      baseline sTNF-R1, the risk of all-cause mortality was
                      increased by about $30\%$ (Hazard ratio 1.28, $95\%$
                      Confidence Interval 0.6-2.7), while per each doubling of the
                      follow-up level of sTNF-R1 mortality was 3-fold (3.11,
                      1.5-6.5) higher in a model including both measurements and
                      adjusting for confounders. The results were mainly related
                      to the cardiovascular mortality (5.9, 2.1-16.8 per each
                      doubling of follow up sTNF-R1 value).Solely the follow-up
                      value, rather than its change from baseline, predicted
                      future mortality. Thus, while sTNF-R1 levels are associated
                      with mortality, particularly cardiovascular, over a
                      long-time period in the general population, if they change,
                      the earlier measurements play no or little role.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33104754},
      doi          = {10.1371/journal.pone.0241213},
      url          = {https://inrepo02.dkfz.de/record/164171},
}