%0 Journal Article
%A Geijsen, Anne J M R
%A Ulvik, Arve
%A Gigic, Biljana
%A Kok, Dieuwertje E
%A van Duijnhoven, Fränzel J B
%A Holowatyj, Andreana N
%A Brezina, Stefanie
%A van Roekel, Eline H
%A Baierl, Andreas
%A Bergmann, Michael M
%A Böhm, Jürgen
%A Bours, Martijn J L
%A Brenner, Hermann
%A Breukink, Stéphanie O
%A Bronner, Mary P
%A Chang-Claude, Jenny
%A de Wilt, Johannes H W
%A Grady, William M
%A Grünberger, Thomas
%A Gumpenberger, Tanja
%A Herpel, Esther
%A Hoffmeister, Michael
%A Huang, Lyen C
%A Jedrzkiewicz, Jolanta D
%A Keulen, Eric T P
%A Kiblawi, Rama
%A Kölsch, Torsten
%A Koole, Janna L
%A Kosma, Katharina
%A Kouwenhoven, Ewout A
%A Kruyt, Flip M
%A Kvalheim, Gry
%A Li, Christopher I
%A Lin, Tengda
%A Ose, Jennifer
%A Pickron, T Bartley
%A Scaife, Courtney L
%A Schirmacher, Peter
%A Schneider, Martin A
%A Schrotz-King, Petra
%A Singer, Marie C
%A Swanson, Eric R
%A van Duijvendijk, Peter
%A van Halteren, Henk K
%A van Zutphen, Moniek
%A Vickers, Kathy
%A Vogelaar, F Jeroen
%A Wesselink, Evertine
%A Habermann, Nina
%A Ulrich, Alexis B
%A Ueland, Per M
%A Weijenberg, Matty P
%A Gsur, Andrea
%A Ulrich, Cornelia M
%A Kampman, Ellen
%T Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival.
%J JNCI cancer spectrum
%V 4
%N 5
%@ 2515-5091
%C Oxford
%I Oxford University Press
%M DKFZ-2020-02351
%P pkaa051
%D 2020
%X Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown.Circulating concentrations of folate, folic acid, and folate catabolites p-aminobenzoylglutamate and p-acetamidobenzoylglutamate were measured by liquid chromatography-tandem mass spectrometry at diagnosis in 2024 stage I-III colorectal cancer patients from European and US patient cohort studies. Multivariable-adjusted Cox proportional hazard models were used to assess associations between folate, folic acid, and folate catabolites concentrations with recurrence, overall survival, and disease-free survival.No statistically significant associations were observed between folate, p-aminobenzoylglutamate, and p-acetamidobenzoylglutamate concentrations and recurrence, overall survival, and disease-free survival, with hazard ratios ranging from 0.92 to 1.16. The detection of folic acid in the circulation (yes or no) was not associated with any outcome. However, among patients with detectable folic acid concentrations (n = 296), a higher risk of recurrence was observed for each twofold increase in folic acid (hazard ratio = 1.31, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33134831
%2 pmc:PMC7583160
%R 10.1093/jncics/pkaa051
%U https://inrepo02.dkfz.de/record/164265